ST 2825 - CAS:894787-30-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	ST 2825 一键复制产品信息
英文名称:	ST 2825
别名:	(2R,4'R,8'AR)-1-[2-[4-[[2-(2,4-二氯苯氧基)乙酰基]氨基]苯基]乙酰基]四氢-6'-氧代螺[吡咯烷-2,7'(6'H)-[2H]吡咯并[2,1-B][1,3]噻嗪]-4'-甲酰胺 (2R,4'R,8a'R)-1-(2-(4-(2-(2,4-dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
CAS No:	894787-30-5	分子式:	C₂₇H₂₈Cl₂N₄O₅S	分子量:	591.51
CAS No:	894787-30-5
分子式:	C₂₇H₂₈Cl₂N₄O₅S
分子量:	591.51

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

S10906 ST 2825 ≥98% (普西唐-psaitong)

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包装规格：

1mg in glass bottle

溶解性：

溶于DMSO（100 mg/mL超声） -20°C

产品描述：

基本信息

产品编号：	S10906
产品名称：	ST 2825
CAS:	894787-30-5	储存条件	粉末	-20℃	四年

分子式：	C27H28Cl2N4O5S		溶于液体	-80℃	6个月
分子量：	591.51			-20℃	1个月
化学名：	(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	1.6906mL	8.4529mL	16.9059mL
5mM	0.3381mL	1.6906mL	3.3812mL
10mM	0.1691mL	0.8453mL	1.6906mL

生物活性

产品描述	一种特异的MyD88二聚化抑制剂。
靶点	MyD88
体外研究	ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization.ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at 5μM ST2825 and 80% inhibition at 10μM ST2825.
体内研究	ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration.The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200mg/kg,5 min prior to i.p.injection with 20μg/kg IL-1β.ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200mg/kg.

推荐实验方法(仅供参考)

细胞实验:

HeLa cells are seeded at 105 cells/mL in a 96-well tissue-culture plate.After incubating overnight,the medium is discarded,and the cells are added with tissue culture medium,10% FBS,containing ST2825 at concentrations ranging from 0.1 to 10μM and DMSO at 0.1% final concentration.The cells are incubated for 6 and 18h and then added with the yellow XTT (0.3mg/mL) for further 2h of incubation.At the end of the incubation periods,reactions are quantified by using a Sirio S Seac microplate reader.

动物实验:

Mice

Mice (female C57Bl/6) are divided into experimental groups of 15 mice.They are injected i.p.with saline (control animals) or recombinant murine IL-1β (20μg/kg).A time-course analysis of IL-6 production established that the peak of cytokine is reached 2h after IL-1β injection.ST2825,administered orally as 0.5% suspension in carboxymethylcellulose (CMC) or CMC alone,is supplied to the experimental mice groups.Two hours after IL-1β injection,the animals are killed,and sera are collected to assay IL-6 levels.Mice,which are treated orally with 100 and 200mg/kg ST2825,shows lower levels of IL-6 versus CMC-treated mice.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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