| 中文名称: | SHU 9119 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | SHU 9119 | ||||
| 别名: | N-乙酰基-L-正亮氨酰-L-alpha-天冬氨酰-L-组氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰-L-赖氨酰胺(2→7)-内酰胺 Ac-Nle-Asp(1)-His-D-2Nal-Arg-Trp-Lys(1)-NH2 | ||||
| CAS No: | 168482-23-3 | 分子式: | C54H71N15O9 | 分子量: | 1074.24 |
| CAS No: | 168482-23-3 | ||||
| 分子式: | C54H71N15O9 | ||||
| 分子量: | 1074.24 | ||||
包装规格：
1mg 5mg in glass bottle
溶解性：
溶于水(20mg/mL超声）
产品描述：
一种有效地人类黑皮素受体 3 和 4 (MC3/4R) 拮抗剂，同时也是 MC5R 的部分激动剂。
Shu 9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.1 In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.
Shu 9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.1 In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.
保存条件：
-20℃
UN码：
HazardClass：
危害声明：
安全说明：
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
