| 中文名称: | 盐酸米安色林 促销 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Mianserin hydrochloride | ||||
| 别名: | 盐酸米安色林 Tolvon;1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride | ||||
| CAS No: | 21535-47-7 | 分子式: | C18H21ClN2 | 分子量: | 300.80 |
| CAS No: | 21535-47-7 | ||||
| 分子式: | C18H21ClN2 | ||||
| 分子量: | 300.80 | ||||
| EINEC: | 244-426-7 | ||||
| EINEC: | 244-426-7 | ||||
基本信息
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产品编号： |
M70083 |
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产品名称： |
Mianserin hydrochloride |
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CAS: |
21535-47-7 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
300.80 |
-20℃ |
1个月 |
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化学名： |
1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
60mg/mL (199.44mM) |
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Ethanol |
21mg/mL (69.8mM) |
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Water |
30mg/mL (99.72mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.3241mL |
16.6207mL |
33.2414mL |
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5mM |
0.6648mL |
3.3241mL |
6.6483mL |
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10mM |
0.3324mL |
1.6621mL |
3.3241mL |
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50mM |
0.0665mL |
0.3324mL |
0.6648mL |
生物活性
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产品描述 |
一种H1受体反向激动剂。 |
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靶点 |
Histamine receptor |
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体外研究 |
Mianserin hydrochloride (Org GB 94) is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant,anxiolytic (antianxiety),hypnotic (sedating),antiemetic (nausea and vomiting-attenuating),orexigenic (appetite-stimulating),and antihistamine effects.It is not approved for use in the US,but its analogue,mirtazapine,is.Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.Mianserin is an antagonist/inverse agonist of the H1,5-HT1D,5-HT2A,5-HT2B,5-HT2C,5-HT3,5-HT6,5-HT7,α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist,mianserin has strong antihistamine effects (sedation, weight gain,etc.).Contrarily, it has negligible affinity for the mACh receptors,and thus lacks any anticholinergic properties.It was recently found to be a potent kappa opioid receptor agonist.In addition,mianserin also appears to be a potent antagonist of the neuronal octopamine receptor.What implications this may have on mood are currently unknown,however octopamine has been implicated in the regulation of sleep,appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin. |
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体内研究 |
在大鼠大脑皮质中，Mianserin通过阻断突触前抑制的α2肾上腺素能受体对去甲肾上腺素（NA）的再摄取有小的或没有影响，诱导再生介导的增强的释放。在新生儿6-OHDA损毁大鼠中，Mianserin衰减M-CPP和SKF38393的影响，这表明多巴胺受体激动剂的效果是由5-HT神经化学系统介导的。在新生儿6-OHDA损毁大鼠的内侧前额叶皮质中，Mianserin（10毫克/公斤，SC）剂量依赖性增加细胞外的多巴胺约6倍。Mianserin也剂量依赖性增加前额皮质的细胞外去甲肾上腺素。 |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
