| 中文名称: | 依巴斯汀 促销 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Ebastine | ||||
| 别名: | 依巴斯汀;艾巴斯啶 LAS-W 090; RP6430 | ||||
| CAS No: | 90729-43-4 | 分子式: | C32H39NO2 | 分子量: | 469.66 |
| CAS No: | 90729-43-4 | ||||
| 分子式: | C32H39NO2 | ||||
| 分子量: | 469.66 | ||||
| MDL: | MFCD00865661 | ||||
包装规格：
5g in glass bottle
产品简介：
一种具有口服活性的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂。Ebastine 可用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。
溶解性：
溶于Ethanol（58.75mg/ml超声）和 DMSO（8.33mg/mL超声）
储备液保存：
-80°C, 2 years
-20°C, 1 year
-20°C, 1 year
靶点：
H1 Receptor
体外研究：
Ebastine (10-500 ng/mL; 24-48 hours) treatment significantly increases the proliferation of HFDPC.
Ebastine (10-500 ng/mL; 24-48 hours) treatment shows dose-dependent increases in Cyclin D1, Cyclin E1, and Cyclin A expression levels. And the expression levels of Cdk4, Cdk2, and Cdc2 are alos increased. Ebastine treatment elevates expression levels of phospho-AKT and phospho-p44/42 extracellular signal-regulated kinase.
Ebastine (10-500 ng/mL; 24-48 hours) treatment shows dose-dependent increases in Cyclin D1, Cyclin E1, and Cyclin A expression levels. And the expression levels of Cdk4, Cdk2, and Cdc2 are alos increased. Ebastine treatment elevates expression levels of phospho-AKT and phospho-p44/42 extracellular signal-regulated kinase.
体内研究：
In rats, after intravenous administration of [14C]Ebastine at 2 mg/kg, the plasma level of radioactivity decreased biphasically with α-phase half-life (t1/2 α) of 1.6 h and β-phase half-life (t1/2 β) of 3.1 h.
Following oral administration of [14C]Ebastine at a dose of 2 mg/kg, the plasma level reached the maximum (Cmax) of 102 ng eq./ml at 2 h and decreased monophasically with t1/2 of 3.9 h. At 20 mg/kg, a monophasic decrease is also observed with Cmax of 1110 ng eq./ml at 4 h and with t1/2 of 4.0 h.
Following oral administration of [14C]Ebastine at a dose of 2 mg/kg, the plasma level reached the maximum (Cmax) of 102 ng eq./ml at 2 h and decreased monophasically with t1/2 of 3.9 h. At 20 mg/kg, a monophasic decrease is also observed with Cmax of 1110 ng eq./ml at 4 h and with t1/2 of 4.0 h.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
HazardClass：
危害声明：
安全说明：
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