| 中文名称: | CGP37157 | ||||
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| 英文名称: | CGP37157 | ||||
| 别名: | CGP37157 CGP37157 | ||||
| CAS No: | 75450-34-9 | 分子式: | C15H11Cl2NOs | 分子量: | 324.22 |
| CAS No: | 75450-34-9 | ||||
| 分子式: | C15H11Cl2NOs | ||||
| 分子量: | 324.22 | ||||
基本信息
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产品编号： |
C11178 |
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产品名称： |
CGP37157 |
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CAS: |
75450-34-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
324.22 |
-20℃ |
1个月 |
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化学名： |
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
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Solubility (25°C)： |
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体外:
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DMSO |
65mg/mL (200.48mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0843mL |
15.4216mL |
30.8433mL |
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5mM |
0.6169mL |
3.0843mL |
6.1687mL |
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10mM |
0.3084mL |
1.5422mL |
3.0843mL |
生物活性
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产品描述 |
一种Na+/Ca2+exchanger抑制剂，可抑制豚鼠心脏线粒体Na+诱导的Ca2+的释放，IC50值为0.8μM。 |
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靶点 |
IC50:0.8μM (Na+/Ca2+ exchanger) |
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体外研究 |
CGP37157 (Compound XVI) is a potent,selective inhibitor of Na+/Ca2+ exchanger,inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria,with an IC50 of 0.8μM.CGP37157 (10μM) shows inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons,modulates intracellular Ca2+ levels via suppresssing voltage-gated calcium channels,and reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads.CGP37157 (10μM) also reduces NMDA-induced excitotoxicity,and such an effect is via attenuating mitochondrial damage and calpain activity in neurons.CGP37157 (10μM) in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells.Moreover,CGP37157 has no inhibitory effect on salinomycin tumor toxicity. |
推荐实验方法(仅供参考)
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细胞实验: |
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Cell toxicity assays are performed. Neurons are exposed to NMDA in HBSS (free of Ca2+ and Mg2+) containing 2.6mM CaCl2,10mM glucose and 10μM glycine for 10 or 30 min at 37℃,depending on the experiment.CGP37157 is present before and during the excitotoxic insult and cell viability is assessed 24h later using Citotox 96 colorimetric assay. All experiments are performed in quadruplicate and the values provided are the normalized mean ±S.E.M.of at least three independent experiments. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
