| 中文名称: | Bay 41-4109 (less active enantiomer) | ||||
|---|---|---|---|---|---|
| 英文名称: | Bay 41-4109 (less active enantiomer) | ||||
| 别名: | Bay 41-4109 (less active enantiomer);Bay41-4109 less active enantiomer;Bay-41-4109 less active enantiomer;Bayer 41-4109 less active enantiomer | ||||
| CAS No: | 476617-51-3 | 分子式: | C18H13ClF3N3O2 | 分子量: | 395.76 |
| CAS No: | 476617-51-3 | ||||
| 分子式: | C18H13ClF3N3O2 | ||||
| 分子量: | 395.76 | ||||
包装规格：
5mg 10mg 100mg in glass bottle
产品简介：
是比BAY 41-4109活性低的对应体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂，IC50值为53 nM。
溶解性：
溶于DMSO（≥ 37 mg/mL)
储备液保存：
-80°C, 6 months
-20°C, 1 month
-20°C, 1 month
靶点：
IC50: 53 nM (HBV, Bay 41-4109)
体外研究：
BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers[2]. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
体内研究：
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
HazardClass：
危害声明：
安全说明：
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参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
