| 中文名称: | Alamandine 一键复制产品信息 | ||||
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| 英文名称: | Alamandine | ||||
| 别名: | Angiotensin A (1-7) Angiotensin A (1-7);CID 145707871 | ||||
| CAS No: | 1176306-10-7 | 分子式: | C40H62N12O9 | 分子量: | 855 |
| CAS No: | 1176306-10-7 | ||||
| 分子式: | C40H62N12O9 | ||||
| 分子量: | 855 | ||||
基本信息
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产品编号： |
A12068 |
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产品名称： |
Alamandine |
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CAS: |
1176306-10-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
855.00 |
-20℃ |
一个月 |
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化学名： |
L-Alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline |
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Solubility (25°C)： |
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体外:
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DMSO |
50mg/mL(58.47mM) |
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Ethanol |
Insoluble |
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Water |
50mg/mL(58.47mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.1696mL |
5.8480mL |
11.6959mL |
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5mM |
0.2339mL |
1.1696mL |
2.3392mL |
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10mM |
0.1170mL |
0.5848mL |
1.1696mL |
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50mM |
0.0234mL |
0.1170mL |
0.2339mL |
生物活性
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产品描述 |
一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。 |
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体外研究 |
Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood. Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling. Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes |
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体内研究 |
Alamandine (0.15μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide |
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Animal Model: |
Male spontaneously hypertensive rats (SHRs, 50-week-old) |
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Dosage: |
0.15μL/h (~50μg/kg/day) |
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Administration: |
Administered by mini-osmotic pumps; for 6 weeks |
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Result: |
Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
