ZK756326 dihydrochloride - CAS:1780259-94-0 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	ZK756326 dihydrochloride 一键复制产品信息
英文名称:	ZK756326 dihydrochloride
CAS No:	1780259-94-0	分子式:	C₂₁H₃₀Cl₂N₂O₃	分子量:	429.38
CAS No:	1780259-94-0
分子式:	C₂₁H₃₀Cl₂N₂O₃
分子量:	429.38

点击下载产品说明书(PDF)

Z10066 ZK756326 dihydrochloride ≥98% (普西唐-psaitong)

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包装规格：

5mg 10mg 25mg 50mg 100mg in glass bottle

溶解性：

溶于水（50mg/mL 超声），溶于DMSO（27.5mg/mL 超声）

产品描述：

基本信息

产品编号：Z10066
产品名称：ZK756326 dihydrochloride
CAS:	1780259-94-0	储存条件	粉末	-20℃	四年

分子式：	C21H30Cl2N2O3		溶于液体	-80℃	六个月
分子量：	429.38			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.3289mL	11.6447mL	23.2894mL
5mM	0.4658mL	2.3289mL	4.6579mL
10mM	0.2329mL	1.1645mL	2.3289mL

生物活性

产品描述

一种非肽趋化因子受体激动剂，作用于 CC 趋化因子受体 CCR8。

靶点/IC50

CCR

体外研究

ZK 756326 inhibits the binding of the CCR8 ligand I-309 (CCL1),with an IC50 value of 1.8μM.ZK 756326 is a full agonist of CCR8,dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.ZK 756326 stimulates extracellular acidification in cells expressing human CCR8.Binding competition assays are performed on a series of other G-protein-coupled receptors to determine whether the interaction of ZK 756326 is specific for CCR8.In these assays,ZK 756326 is tested at 50μM for inhibition of radiolabeled ligand binding.At this concentration,ZK 756326 shows>28 fold specificity for CCR8 compared with 26 other GPCRs,all with IC50 values of >50μM.There is less selectivity when ZK 756326 is tested against the serotonergic receptors 5-HT1A, 5-HT2B,5-HT2C,5-HT5A,5-HT6,and the adrenergic receptor α2A,in which IC50 values of 5.4,4,4,34.8,16,5.9,and<20μM (at 20μM 65% inhibition),respectively,are observed.The compound is unlikely to be an agonist on these biogenic amine receptors,because when tested at concentrations up to 10μM on a representative receptor,5-HT1A,it shows no agonist activity in a GTPγS binding assay.

推荐实验方法(仅供参考)

细胞实验:

U87 MG cells expressing CCR8 are plated on poly-D-lysine-coated black 96-well plates at 10,000 cells/well and are cultured overnight.Cells are then loaded with Calcium 3,a Ca2+-sensitive non wash fluorescence dye,for 60 min at 37℃ in Hanks' balanced salts solution containing 20mM HEPES,3.2mM CaCl2,1% (v/v) fetal bovine serum,and 2.5mM probenecid.Changes in intracellular free-Ca2+concentration are measured with Fluorometric Imaging Plate Reader (FLIPR 3) immediately after the addition of agonist at room temperature.Cross-desensitization experiments are performed by a first addition of the agonist (CCL1 at 30nM or ZK 756326 at 3μM),immediately followed by a second addition of 100 nM CCL1.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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