| 中文名称: | 伐地那非二盐酸盐 | ||||
|---|---|---|---|---|---|
| 英文名称: | Vardenafil dihydrochloride | ||||
| 别名: | 瓦地那非二盐酸盐(2-[2-乙氧基-5-(4-乙基-哌嗪-1-磺酰基)苯基]-5-甲基-7-丙基-3H-咪唑[5,1-F]-[1,2,4]三联氮-4-酮二盐酸盐、伐地那非二盐酸盐);瓦地那非二盐酸盐标准溶液;二盐酸伐地那非;盐酸盐伐地那非;伐地那非二盐酸盐;瓦地那非二盐酸盐;2-[2-乙氧基-5-(4-乙基-哌嗪-1-磺酰基)苯基]-5-甲基-7-丙基-3H-咪唑[5,1-f]-[1,2,4]三联氮-4-酮二盐酸盐 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazinedihydrochloride;Levitra;Vardenafildihydrochloride;2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-onedihydrochloride;2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-onedihydrochloride | ||||
| CAS No: | 224789-15-5 | 分子式: | C23H33ClN6O4S | 分子量: | 525.07 |
| CAS No: | 224789-15-5 | ||||
| 分子式: | C23H33ClN6O4S | ||||
| 分子量: | 525.07 | ||||
熔点：
214-216°C
包装规格：
10mg in glass bottle
产品简介：
一种选择性 5 型磷酸二酯酶 (PDE5) 抑制剂。现已发现PDE至少有11种同工酶PDE5主要存在于血小板和血管平滑肌，尤其是在阴茎海绵体中，可以介导勃起反应。
溶解性：
DMSO :100 mg/mL (190.45 mM)
Ethanol：20 mg/mL (38.09 mM)
Water：100 mg/mL (190.45 mM)
Ethanol：20 mg/mL (38.09 mM)
Water：100 mg/mL (190.45 mM)
靶点：
PDE5:0.7 nM (IC50)
PDE1:180 nM (IC50)
PDE6:11 nM (IC50)
体外研究：
Vardenafil dihydrochloride specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 value of 0.7 nM.
Vardenafil dihydrochloride increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow.
Vardenafil dihydrochloride increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow.
体内研究：
Vardenafil dihydrochloride (0.03 mg/kg; i.v.) exhibits facilitator effects in rats with cavernous nerve injury.
Vardenafil dihydrochloride (0.17 mg/kg; i.v.; once daily; 7 d) protects liver against Con A–induced hepatitis, and decreases the expression of NF-𝜅B and iNOS in hepatic tissue.
Vardenafil dihydrochloride (10 mg/kg; p.o.; once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts.
Vardenafil dihydrochloride (0.17 mg/kg; i.v.; once daily; 7 d) protects liver against Con A–induced hepatitis, and decreases the expression of NF-𝜅B and iNOS in hepatic tissue.
Vardenafil dihydrochloride (10 mg/kg; p.o.; once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts.
保存条件：
室温 避光
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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安全说明：
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参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
