| 中文名称: | Tolterodine tartrate 一键复制产品信息 | ||||
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| 英文名称: | Tolterodine tartrate | ||||
| 别名: | (R)-2-(3-(二异丙胺基)-1-苯基丙基)-4-甲基苯酚 (2R,3R)-2,3-二羟基琥珀酸盐 Kabi-2234; PNU-200583E；(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol (2R,3R)-2,3-dihydroxysuccinate | ||||
| CAS No: | 124937-52-6 | 分子式: | C26H37NO7 | 分子量: | 475.57 |
| CAS No: | 124937-52-6 | ||||
| 分子式: | C26H37NO7 | ||||
| 分子量: | 475.57 | ||||
基本信息
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产品编号： |
T60031 |
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产品名称： |
Tolterodine tartrate |
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CAS: |
124937-52-6 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
475.57 |
-20℃ |
1个月 |
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化学名： |
(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol (2R,3R)-2,3-dihydroxysuccinate |
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Solubility (25°C)： |
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体外:
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DMSO |
95mg/mL (199.76mM) |
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Water |
17mg/mL (35.74mM) |
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Ethanol |
6mg/mL (12.61mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1027mL |
10.5137mL |
21.0274mL |
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5mM |
0.4205mL |
2.1027mL |
4.2055mL |
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10mM |
0.2103mL |
1.0514mL |
2.1027mL |
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50mM |
0.0421mL |
0.2103mL |
0.4205mL |
生物活性
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产品描述 |
一种有效的毒蕈碱受体拮抗剂，体内对膀胱具有选择性。 |
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靶点 |
AChR |
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体外研究 |
Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14nM) and 5-HM (IC50 5.7nM).The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27,200 and 370-485 times higher,respectively,than its potency in blocking histamine receptors,alpha-adrenoceptors and calcium channels.The active metabolite, 5-HM,was >900 times less potent at these sites than at bladder muscarinic receptors. |
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体内研究 |
Tolterodine was extensively metabolized in vivo.In the passive-avoidance test,tolterodine at 1 or 3mg/kg had no effect on memory;the latency to cross and percentage of animals crossing were comparable to controls.In contrast,scopolamine induced a memory deficit;the latency to cross was decreased,and the number of animals crossing was increased. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
