TB5 - CAS:948841-07-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	TB5 一键复制产品信息
英文名称:	TB5
别名:	(E)-1-(5-Bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
CAS No:	948841-07-4	分子式:	C₁₅H₁₄BrNOs	分子量:	336.25
CAS No:	948841-07-4
分子式:	C₁₅H₁₄BrNOs
分子量:	336.25

点击下载产品说明书(PDF)

T11464 TB5 ≥95% (普西唐-psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

产品描述：

基本信息

产品编号：	T11464
产品名称：	TB5
CAS:	948841-07-4	储存条件	粉末	-20℃	四年

分子式：	C15H14BrNOs		溶于液体	-80℃	两年
分子量	336.25			-20℃	1个月
化学名：	(E)-1-(5-Bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
Solubility (25°C)：
体外:	DMSO	67 mg/mL (199.25mM)
	Ethanol	2 mg/mL (5.94mM)
	Water	Insoluble
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.9740mL	14.8699mL	29.7398mL
5mM	0.5948mL	2.9740mL	5.9480mL
10mM	0.2974mL	1.4870mL	2.9740mL
50mM	0.0595mL	0.2974mL	0.5948mL

生物活性

产品描述	一种具有有效性，选择性和可逆性的 hMAO-B 抑制剂，Ki 值为 0.11±0.01μM。
靶点	MAO-B ()
靶点	110nM(Ki)
体外研究	TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
体内研究	Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.

推荐实验方法(仅供参考)

Kinase Assay

Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8

Cell Assay

In vitro cytotoxicity of brominated thiophene chalcones and standard MAO inhibitors are tested in human HepG2 hepatic cancer cells at three different concentrations (1, 5 and 25μM).

保存条件：

-20℃

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