| 中文名称: | TEI-9647 | ||||
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| 英文名称: | TEI-9647 | ||||
| 别名: | TEI-9647 (23S)-1alpha-Hydroxy-25,27-didehydrovitamin D3 26,23-lactone | ||||
| CAS No: | 173388-20-0 | 分子式: | C27H38O4 | 分子量: | 426.6 |
| CAS No: | 173388-20-0 | ||||
| 分子式: | C27H38O4 | ||||
| 分子量: | 426.6 | ||||
基本信息
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产品编号： |
T11347 |
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产品名称： |
TEI-9647 |
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CAS: |
173388-20-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
426.60 |
-20℃ |
1个月 |
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化学名： |
(23S)-1alpha-Hydroxy-25,27-didehydrovitamin D3 26,23-lactone |
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Solubility (25°C)： |
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体外:
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DMSO |
100 mg/mL (234.42mM; Need ultrasonic) |
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Water |
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Ethanol |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.3442mL |
11.7209mL |
23.4417mL |
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5mM |
0.4688mL |
2.3442mL |
4.6883mL |
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10mM |
0.2344mL |
1.1721mL |
2.3442mL |
生物活性
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产品描述 |
一种 Vitamin D3 Lactone 类似物，是一种有效的，特异性的维生素 D 受体 (VDR) 拮抗剂。 TEI-9647 抑制 VDR/VDRE 介导的 1α,25(OH)2D3 的基因组作用。TEI-9647 可以抑制 1α,25(OH)2D3 诱导的骨吸收和 HL-60 细胞分化。TEI-9647 有潜力用于抑制 Paget 病中过度的骨吸收和破骨细胞形成。 |
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靶点 |
VD/VDR |
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体外研究 |
TEI-9647 (100nM; 24 hours) treatment clearly suppresses p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3 . TEI-9647 (10-1000nM; 96 hours) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3. TEI-9647 completely blocks the increase in CD11b and the decrease in CD71 expression at 100nM. TEI-9647 blocks both 1α,25(OH)2D3-mediated HL-60 cell differentiation and also activation of the luciferase reporter in COS-7 cells that has been transfected with the cDNA containing the DRE of the rat 25(OH)D3-24-hydroxylase gene and cDNA of the human vitamin D nuclear receptor . TEI-9647 can not induce cell differentiation even after treatment at 1μM in HL-60 cell. TEI-9647 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9647 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1nM) in HL-60 cells. TEI-9647 (0.001-1μM; for 10 days) dose-dependently inhibits bone resorption induced by of 1α,25(OH)2D3 (1nM). TEI-9647 alone never induces bone resorption even at 1μM . TEI-9647 (10nM; 12 h) markedly inhibits TAFII-17 and 25-OH-D3-24-hydroxylase gene expression induced by 1α,25(OH)2D3 (0.1nM) in bone marrow cells. RT-PCR
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Cell Line: |
HL-60 cells |
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Concentration: |
100nM |
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Incubation Time: |
24 hours |
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Result: |
Clearly suppressed p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
