| 中文名称: | Sufugolix 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Sufugolix | ||||
| 别名: | 其他生物活性分子 TAK-013; TAK013; 1-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea | ||||
| CAS No: | 308831-61-0 | 分子式: | C36H31F2N5O4S | 分子量: | 667.73 |
| CAS No: | 308831-61-0 | ||||
| 分子式: | C36H31F2N5O4S | ||||
| 分子量: | 667.73 | ||||
一种口服有效的LHRH(黄体激素释放激素)受体拮抗剂，IC50值为0.1nM。
Sufugolix is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). It was under development for the treatment of endometriosis and uterine leiomyoma and reached phase II clinical trials for both of these indications, but was subsequently discontinued. It seems to have been supplanted by relugolix (TAK-385), which is also under development by Takeda for the treatment of these conditions and has a more favorable drug profile (including reduced cytochrome P450 inhibition and improved in vivo GnRHR antagonistic activity) in comparison.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
