| 中文名称: | RN-1734 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | RN-1734 | ||||
| 别名: | RN-1734 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide | ||||
| CAS No: | 946387-07-1 | 分子式: | C14H22Cl2N2O2S | 分子量: | 353.31 |
| CAS No: | 946387-07-1 | ||||
| 分子式: | C14H22Cl2N2O2S | ||||
| 分子量: | 353.31 | ||||
基本信息
|
产品编号： |
R10393 |
||||
|
产品名称： |
RN-1734 |
||||
|
CAS: |
946387-07-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
6个月 |
||
|
分子量： |
353.31 |
-20℃ |
1个月 |
||
|
化学名： |
2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
71mg/mL (200.95mM) |
|||
|
Ethanol |
71mg/mL (200.95mM) |
||||
|
Water |
Insoluble |
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.8304mL |
14.1519mL |
28.3038mL |
|
5mM |
0.5661mL |
2.8304mL |
5.6608mL |
|
10mM |
0.2830mL |
1.4152mL |
2.8304mL |
生物活性
|
产品描述 |
一种选择性TRPV4通道拮抗剂 |
|
|
靶点 |
IC50:2.3μM (hTRPV4),5.9μM (mTRPV4),3.2μM (rTRPV4) |
|
|
体外研究 |
RN-1734 (27 hours;10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis.RN-1734 (27 hours;10μM) alleviates CM-induced decreases in CNP. Apoptosis Analysis |
|
|
Cell Line: |
Microglial cells |
|
|
Concentration: |
27 hours |
|
|
Incubation Time: |
10μM |
|
|
Result: |
Significantly decreased the percentage of cleaved-caspase 3 positive cells. |
|
|
Western Blot Analysis |
||
|
Cell Line: |
Microglial cells |
|
|
Concentration: |
27 hours |
|
|
Incubation Time: |
10μM |
|
|
Result: |
Alleviated CM (with LPS only)-induced decreases in CNP. |
|
|
体内研究 |
RN-1734 (0.5μl;microinjector pump;daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse. |
|
|
Animal Model: |
CPZ-induced demyelination mouse model (C57BL/6 male mice) |
|
|
Dosage: |
0.5μl (10μM in 5% DMSO and 0.9% NaCl) |
|
|
Administration: |
Microinjector pump for 5 weeks |
|
|
Result: |
Significantly reversed the decrease in CNP protein and improved myelination in CPZinduced demyelination mouse. |
|
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
