Progabide - CAS:62666-20-0 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Progabide 一键复制产品信息
英文名称:	Progabide
别名:	普罗加比 SL76002
CAS No:	62666-20-0	分子式:	C₁₇H₁₆ClFN₂O₂	分子量:	334.77
CAS No:	62666-20-0
分子式:	C₁₇H₁₆ClFN₂O₂
分子量:	334.77
EINEC:	263-679-4
EINEC:	263-679-4

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

P11267 Progabide (普西唐-psaitong)

相关产品

包装规格：

5mg in glass bottle

产品描述：

基本信息

产品编号：	P11267
产品名称：	Progabide
CAS:	62666-20-0	储存条件	粉末	-20℃	四年
分子式：	C17H16ClFN2O2		溶于液体	-80℃	一年
分子量：	334.77
化学名：	4-[[(E)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

生物活性

产品描述	一种γ-氨基丁酸(GABA)受体激动剂。
靶点	GABA receptor
体内研究	Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.Doses of 50,100 and 200mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244,365 and 476% respectively (t=6.44 to12.55,p<0.01).10mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76,N.S.).The increased plasma corticosterone level induced by administration of 200mg/kg Progabide is evident 30 (t=2.625,p<0.05),60 (t=13.13,p<0.001) and 120 min (t=4.07,p<0.01) after drug injection,but returns to the control value 240 min after drug injection (t=0.86,N.S.).The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.

推荐实验方法(仅供参考)

动物实验:

Male Wistar rats weighing 170 to 240g are caged in groups of three under diurnal lighting conditions with free access to food and water.The rats are accustomed to handling (housing 1 per cage for 30 min,injecting with saline,1mL/100g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80.Control rats are treated IP with the corresponding vehicle (1mL/100g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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