盐酸苯乙福明 - CAS:834-28-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	盐酸苯乙福明
英文名称:	Phenformin hydrochloride
别名:	盐酸苯乙福明 Phenethylbiguanide hydrochloride
CAS No:	834-28-6	分子式:	C₁₀H₁₆ClN₅	分子量:	241.72
CAS No:	834-28-6
分子式:	C₁₀H₁₆ClN₅
分子量:	241.72
EINEC:	212-637-3
EINEC:	212-637-3

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P10867 盐酸苯乙福明 ≥98% (psaitong)

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包装规格：

5g 25g 100g in poly bottle

产品描述：

基本信息

产品编号：P10867
产品名称：Phenformin hydrochloride
CAS:	834-28-6	储存条件	粉末	2-8℃(氮气保存)	四年
分子式：	C10H16ClN5		溶于液体	-80℃(氮气保存)	六个月
分子量：	241.72			-20℃(氮气保存)	一个月
化学名：
Solubility (25°C)	体外	DMSO	Insoluble
		Ethanol	Insoluble
		Water	48mg/mL (198.57mM)
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	4.1370mL	20.6851mL	41.3702mL
5mM	0.8274mL	4.1370mL	8.2740mL
10mM	0.4137mL	2.0685mL	4.1370mL
50mM	0.0827mL	0.4137mL	0.8274mL

生物活性

产品描述	Phenformin hydrochloride 是一种双胍类的抗糖尿病药，能够使 AMPK 活化。
靶点/IC50	AMPK (Cell-free assay)
体外研究	Phenformin stimulates the phosphorylation and activation of AMPKalpha1 and AMPKalpha2 without altering LKB1 activity.Phenformin increases AMPK activity and phosphorylation in the isolated heart, the increase in AMPK activity is always preceded by and correlated with increased cytosolic [AMP].Phenformin is a 50-fold more potent inhibitor of mitochondrial complex I than metformin. Phenformin robustly induces apoptosis in LKB1 deficient NSCLC cell lines.Phenformin at 2mM similarly induces AMPK signaling as shown by increased P-AMPK and P-Raptor levels.Phenformin induces higher levels of cellular stress,triggering induction of P-Ser51 eIF2αand its downstream target CHOP,and markers of apoptosis at later times.Phenformin induces a significant increase in survival and therapeutic response in KLluc mice following long-term treatment.Phenformin and AICAR increases AMPK activity in H441 cells in a dose-dependent fashion,stimulating the kinase maximally at 5-10mm and 2mm,respectively. Phenformin significantly decreases basal ion transport (measured as short circuit current) across H441 monolayers by approximately 50% compared with that of controls.Phenformin and AICAR significantly reduce amiloride-sensitive transepithelial Na+ transport compared with controls.Phenformin and AICAR suppress amiloride-sensitive Na+transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+entry through ENaC and basolateral Na+extrusion via the Na+,K+-ATPase.Phenformin-treated rats reveals a tendency towards a decrease in blood insulin level (radioimmunoassay).
体内研究	Phenformin increases levels of P-eIF2αand its target BiP/Grp78 in normal lung as well as in lung tumors of mice.

推荐实验方法(仅供参考)

激酶实验：

Total AMPK activity is measured using the method of Dagher et al.AMPK activity is quantified in the resuspended pellet as incorporation of 32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK,the SAMS peptide.Radioactivity is measured using a liquid scintillation counter.Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method.

保存条件：

2-8℃ 充氮保存

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果