| 中文名称: | Lazabemide hydrochloride 一键复制产品信息 | ||||
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| 英文名称: | Lazabemide hydrochloride | ||||
| 别名: | Ro 19-6327 hydrochloride；N-(2-aminoethyl)-5-chloropyridine-2-carboxamide;hydrochloride | ||||
| CAS No: | 103878-83-7 | 分子式: | CH11Cl2N3O | 分子量: | 236.1 |
| CAS No: | 103878-83-7 | ||||
| 分子式: | CH11Cl2N3O | ||||
| 分子量: | 236.1 | ||||
基本信息
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产品编号： |
L11031 |
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产品名称： |
Lazabemide hydrochloride |
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CAS: |
103878-83-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
236.10 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种单胺氧化酶 B (MAO-B) 的选择性的可逆抑制剂(IC50=0.03μM)，但对 MAO-A (IC50>100μM) 活性较低。高浓度 Lazabemide 具有抑制单胺摄取的作用，抑制去甲肾上腺素、血清素和多巴胺摄取的 IC50 值分别为 86μM、123μM 和 >500μM。Lazabemide 可用于帕金森和阿尔茨海默病的研究。 |
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靶点 |
MAO-B 0.4nM (IC50) |
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体外研究 |
The in vitro binding characteristics of both radiolabeled inhibitors revealed them to be selective, high-affinity ligands for the respective enzymes. KD and Bmax values for 3H-Ro 19-6327 in rat cerebral cortex are 18.4 nM and 3.45 pmol/mg protein, respectively. The IC50 values for lazabemide are: 86 μM for NA uptake; 123μM for 5HT uptake; > 500μM for DA uptake, respectively. Lazabemide (5μM) inhibits human MAO-B and MAO-A with IC50 of 6.9nM and >10nM, respectively. And it inhibits rat MAO-B and MAO-A with IC50of 37nM and >10μM, respectively ina enzymatic assay. Lazabemide differs from L-deprenyl in their ability to induce release of endogenous monoamines from synaptosomes. Thus, Lazabemide (500μM) induces a greater 5 HT release than does L-deprenyl, but is less effective than L-deprenyl in releasing DA. On the contrary, lazabemide was almost completely inactive on either 5 HT and DA release. Lazabemide (250nM) results in a clear inhibition of DOPAC formation, while does not increase the accumulation of newlyformed DA in those tubular epithelial cells loaded with 50microM L-DOPA. |
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体内研究 |
Lazabemide (3 mg/kg) attenuates ichemia reperfusion-induced hydroxyl radical generation and pretreatment with Lazabemide showed decreased DOPAC levels in comparison with those of their respective vehicle-treated control groups. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
