| 中文名称: | 7-羟基甲氨蝶呤 | ||||
|---|---|---|---|---|---|
| 英文名称: | 7-Hydroxymethotrexate | ||||
| 别名: | (S)-2-(4-(((2,4-二氨基-7-氧代-7,8-二氢蝶呤-6-基)甲基)(甲基)氨基)苯甲酰胺基)戊二酸 (S)-2-(4-(((2,4-Diamino-7-oxo-7,8-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid | ||||
| CAS No: | 5939-37-7 | 分子式: | C20H22N8O6 | 分子量: | 470.44 |
| CAS No: | 5939-37-7 | ||||
| 分子式: | C20H22N8O6 | ||||
| 分子量: | 470.44 | ||||
Methotrexate (MTX) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂，可以抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。
7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models. It and the parent compound rapidly accumulate when all three transporters are absent.2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Various methods have been described to quantify 7-hydroxy MTX levels during cancer therapy to avoid toxicity.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
