辅酶Q10 - CAS:303-98-0 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	辅酶Q10 促销文献数量：1 一键复制产品信息
英文名称:	Coenzyme Q10
别名:	Q-10 泛醌 Coenzyme Q10
CAS No:	303-98-0	分子式:	C₅₉H₉₀O₄	分子量:	863.34
CAS No:	303-98-0
分子式:	C₅₉H₉₀O₄
分子量:	863.34
MDL:	MFCD00042919	EINEC:	206-147-9
EINEC:	206-147-9

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C10242 辅酶Q10 ≥98%,分析标准品 (普西唐-psaitong)

相关产品

外观与性状：

黄色粉末

包装规格：

20mg in glass bottle

产品描述：

基本信息

产品编号：	C10242
产品名称：	Coenzyme Q10
CAS:	303-98-0	储存条件	粉末	-20℃	四年

分子式：	C59H90O4		溶于液体	-80℃	两年
分子量	863.34
化学名：	((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
Solubility (25°C)：
体外:	DMSO	Insoluble
	Ethanol
	Water	Insoluble
体内(现配现用):	1.请依序添加每种溶剂：10% DMF→90% (20% SBE-β-CD in saline) Solubility: 3mg/mL (3.47mM); Suspended solution; Need ultrasonic
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	1.1583mL	5.7915mL	11.5829mL
5mM	0.2317mL	1.1583mL	2.3166mL
10mM	0.1158mL	0.5791mL	1.1583mL

生物活性

产品描述	一种线粒体的电子传递链成分，它帮助质子和电子穿过线粒体内膜。
靶点	Human Endogenous Metabolite
体外研究	Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics.
体内研究	Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis

推荐实验方法(仅供参考)

Animal Administration

Rats

The effects of oral administration of coenzyme Q10 on 3-NP-induced striatal lesions are examined in 300- to 350-g rats (n=5- 10). Animals receive either rat chow supplemented with coenzyme Q10 at 200mg/kg or unsupplemented rat chow. After 1 week they are treated with 3-NP at a dose of 10mgykg i.p. twice a day until either a control or treated animal became symptomatic with hindlimb dystonia, and then sacrificed in pairs

Mice

To determine whether coenzyme Q10 exerts neuroprotective effects in a transgenic mouse model of a human neurodegenerative disorder, coenzyme Q10 (200mg/kg) is administered orally to 16 transgenic mice overexpressing a human CuyZn superoxide dismutase (SOD1) mutation, as compared with 13 animals that receive unsupplemented rat chow. The mice used are the G1 line, which expresses high levels of human SOD with the G93A mutation. Treatment is started at 50 days after birth. Treatment is continued until mice reach end-stage disease

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

客户发表文献

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果