| 中文名称: | BTM-1086 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | BTM-1086 | ||||
| 别名: | BTM-1086 | ||||
| CAS No: | 72293-17-5 | 分子式: | C21H25N3Os | 分子量: | 367.51 |
| CAS No: | 72293-17-5 | ||||
| 分子式: | C21H25N3Os | ||||
| 分子量: | 367.51 | ||||
包装规格：
25mg 50mg 100mg in glass bottle
产品简介：
一种有效的抗溃疡和胃分泌抑制剂。
靶点：
Muscarinic receptor
体外研究：
Functional and binding experiments shows that the (-) enantiomer (BTM-1086) has a high affinity (pKi=8.31-9.15) for the three muscarinic receptor subtypes in guinea-pig cortex (M1), heart (M2) and salivary glands (M3).
体内研究：
BTM-1086 prevents the development of ulcer at a dose of 0.1 to 1 mg/kg, p.o., but only weakly inhibits the histamine induced gastric ulcer. The inhibitory activities of BTM-1086 are significantly higher than those of atropine sulfate. In the healing experiment with the acetic acid-induced stomach ulcer, BTM-1086 (1 mg/kg/day , p.o., x14) shows a significant healing effect, which is higher than that of propantheline bromide . BTM-1086 at a dose of 0.2 mg/kg , i.d., remarkably inhibits the gastric secretion 6 hr after pylorus ligation. The aspirin-induced reductions of the total acid and K+ as well as the increments of the volume and Na+ in the gastric secretion are prevented dose-dependently by pretreatment with BTM-1086. The LD50 value by oral, s.c., and i.v. administration with this compound is 880, 630 and 113 mg/kg, respectively, for male rats and 830, 650 and 119 mg/kg, respectively, for female rats.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
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危害声明：
安全说明：
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