| 中文名称: | Anipamil 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Anipamil | ||||
| 别名: | 阿尼帕米 Anipamil | ||||
| CAS No: | 83200-10-6 | 分子式: | C34H52N2O2 | 分子量: | 520.79 |
| CAS No: | 83200-10-6 | ||||
| 分子式: | C34H52N2O2 | ||||
| 分子量: | 520.79 | ||||
包装规格：
1mg in glass bottle
产品简介：
一种长效的calciumchannel阻滞剂，常用于心血管疾病研究。
体内研究：
Anipamil (40 mg, p.o.)-treated 2K-1C rabbits reveal absent or negligible intimal thickening and a decrease of postnatal-type SMC from the underlying media. Anipamil inhibits the growth of SMC accompanied by the expression of SM-MyHC in all SMC, ie, the appearance of a more differentiated cell phenotype compared to control cultures. In the arrhythmic assay, anipamil (1.0 mg/kg + 0.10 mg/kg/min infusion, n=8 or 5.0 mg/kg + 0.50 mg/kg/min infusion, n=12) reduces VT but not VF. In rats with subtotal (five-sixths) nephrectomy treated with anipamil (0.5 mg/kg/day, p.o.), the mortality is less, and the mean arterial blood pressure is also more well controlled, and the serum creatinine concentration is lower than control group. The anipamil (2 mg/kg/day)-treated group exhibits significantly greater protection of renal function than does the hydralazine-treated group for the same level of blood pressure control.
保存条件：
-20℃
注意事项：
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2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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