| 中文名称: | 阿非迪霉素 一键复制产品信息 | ||||
|---|---|---|---|---|---|
| 英文名称: | Aphidicolin | ||||
| 别名: | 艾菲地可宁 (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol | ||||
| CAS No: | 38966-21-1 | 分子式: | C20H34O4 | 分子量: | 338.48 |
| CAS No: | 38966-21-1 | ||||
| 分子式: | C20H34O4 | ||||
| 分子量: | 338.48 | ||||
包装规格：
1mg in glass bottle
产品简介：
Aphidicolin 是 DNA 聚合酶 α 和 δ 抑制剂，通过干扰 DNA 聚合酶的活性来阻止细胞有丝分裂。Aphidicolin 是一种来源于 Cephalosporium aphidicola 的抗生素, 能够抑制细胞脱氧核糖核酸合成和单纯疱疹病毒生长。Aphidicolin 具有抗正痘病毒活性，能够增强阿拉伯糖基核苷对细胞凋亡 (apoptosis) 的诱导作用。
溶解性：
溶于DMSO(50mg/ml)和甲醇(10mg/mL)
储备液保存：
-80°C, 6 months
-20°C, 1 month
-20°C, 1 month
体外研究：
Aphidicolin (0.5 μM, 5 μM; 0-5 d) selectively kills neuroblastoma cells, but shows moderate cytotoxicity on normal human embryonal cells and HeLa, H9, A549 and Caco-2 cell lines.
Aphidicolin (0.4 μg/mL; 3 d) arrests cell cycle at G2 phase. Aphidicolin (100 nM-10 µM; 48 h) inhibits cell proliferation via the p53-GADD45β pathway and (1 µM; 24 h) induces apoptosis in AtT-20 cells.
Aphidicolin (10 µM; 0-6 h) decreases the phosphorylation of Akt, (100 nM-10 µM; 24 h) increases the mRNA levels of the stress response gene growth arrest and DNA damage-inducible 45β (GADD45β), a putative downstream target of p53.
Aphidicolin (10 µM; 0-6 h) inhibits Varicella-zoster virus (VZV) with EC50s of 0.5-0.6 μM, with low cytotoxicity.
Aphidicolin (0.4 μg/mL; 3 d) arrests cell cycle at G2 phase. Aphidicolin (100 nM-10 µM; 48 h) inhibits cell proliferation via the p53-GADD45β pathway and (1 µM; 24 h) induces apoptosis in AtT-20 cells.
Aphidicolin (10 µM; 0-6 h) decreases the phosphorylation of Akt, (100 nM-10 µM; 24 h) increases the mRNA levels of the stress response gene growth arrest and DNA damage-inducible 45β (GADD45β), a putative downstream target of p53.
Aphidicolin (10 µM; 0-6 h) inhibits Varicella-zoster virus (VZV) with EC50s of 0.5-0.6 μM, with low cytotoxicity.
体内研究：
Aphidicolin, has been developed with higher solubility agent, namely Aphidicolin glycinate (AG; NSC 303812).
Aphidicolin glycinate (100 mg/kg; i.p.; once every 3 h; 9 d) shows anti-tumor activity against the implanted B16 melanoma and M5076 sarcoma in murine, producing maximum increased life spans of 75%.
Aphidicolin glycinate (100 mg/kg; i.p.; once every 3 h; 9 d) shows anti-tumor activity against the implanted B16 melanoma and M5076 sarcoma in murine, producing maximum increased life spans of 75%.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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