2020-10-20

1: Vito VD, Saba A, Lee HK, Owen H, Poapolathep A, Giorgi M. Detection and 
quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in 
canine plasma by HPLC with spectrofluorimetric detection. J Pharm Biomed Anal. 
2016 Jan 25;118:251-8. doi: 10.1016/j.jpba.2015.11.004. Epub 2015 Nov 7. PubMed 
PMID: 26580822.

2: Okumura T, Murata Y, Taniguchi K, Murase A, Nii A. Effects of the selective 
EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat 
adjuvant-induced arthritis. J Pharm Pharmacol. 2008 Jun;60(6):723-30. doi: 
10.1211/jpp.60.6.0007. PubMed PMID: 18498708.

3: Murase A, Nakao K, Takada J. Characterization of binding affinity of 
CJ-023,423 for human prostanoid EP4 receptor. Pharmacology. 2008;82(1):10-4. doi: 
10.1159/000125674. Epub 2008 Apr 11. PubMed PMID: 18408415.

4: Nakao K, Murase A, Ohshiro H, Okumura T, Taniguchi K, Murata Y, Masuda M, Kato 
T, Okumura Y, Takada J. CJ-023,423, a novel, potent and selective prostaglandin 
EP4 receptor antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 
2007 Aug;322(2):686-94. Epub 2007 May 10. PubMed PMID: 17495127.