| 中文名称: | 红景天苷 促销 | ||||
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| 英文名称: | Salidroside | ||||
| 别名: | 对羟基苯基吡喃葡萄糖苷 (2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahydro-2H-pyran-3,4,5-triol | ||||
| CAS No: | 10338-51-9 | 分子式: | C14H20O7 | 分子量: | 300.3 |
| CAS No: | 10338-51-9 | ||||
| 分子式: | C14H20O7 | ||||
| 分子量: | 300.3 | ||||
基本信息
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产品编号： |
S70093 |
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产品名称： |
Salidroside |
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CAS: |
10338-51-9 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
300.30 |
-20℃ |
一个月 |
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化学名： |
(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-(4-hydroxyphenethoxy)tetrahydro-2H-pyran-3,4,5-triol |
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Solubility (25°C)： |
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体外:
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DMSO |
60mg/mL (199.8mM) |
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Ethanol |
4mg/mL (13.32mM) |
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Water |
60mg/mL (199.8mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.3300mL |
16.6500mL |
33.3000mL |
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5mM |
0.6660mL |
3.3300mL |
6.6600mL |
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10mM |
0.3330mL |
1.6650mL |
3.3300mL |
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50mM |
0.0666mL |
0.3330mL |
0.6660mL |
生物活性
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产品描述 |
Salidroside (Rhodioloside) 是一种糖苷类化合物，作用于SACC-2细胞增殖，IC50为4.99±0.23μg/mL。 |
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体外研究 |
Salidroside浓度和时间依赖性抑制各种人类癌细胞系的生长，并且这些癌细胞系对salidroside的敏感度不同。Salidroside能够引起不同癌细胞系中G1期和G2期的停滞，同时，salidroside导致CDK4，细胞周期蛋白D1，细胞周期蛋白B1 和 Cdc2减少，并且上调p27(Kip1)和p21(Cip1)的水平。在培养的NGF分化的PC12细胞中， Salidroside通过激活ERK1/2通路并抑制胱天蛋白酶-3激活，会减轻细胞活性的损失和H(2)O(2)刺激诱导的细胞凋亡。Salidroside激活PI3K/Akt通路，引起对PC12细胞中MPP(+)诱导的细胞凋亡产生保护作用，这可能可以用于帕金森综合症(PD)的治疗。 |
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体内研究 |
Salidroside (20，50 和100 毫克/千克)保护肝脏组织免受D-半乳糖胺和脂多糖引起的氧化应激。 |
推荐实验方法(仅供参考)
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Cell Assay |
SH-SY5Y cells are seeded in 96-well plates at 1×104 cells per well. After the treatment with Salidroside (25-100μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500μg/mL MTT at 37°C for 4 h. After that, the medium is removed and 150μL DMSO is added and shaking is conducted for 10 min. Absorbance is measured at 570nm in a microplate reader and the results are expressed as folds of control |
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Animal Administration |
Mice The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
