MM-102 TFA - CAS:1883545-52-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	MM-102 TFA
英文名称:	MM-102 TFA
别名:	HMTase Inhibitor IX TFA
CAS No:	1883545-52-5	分子式:	C₃₇H₅₀F₅N₇O₆	分子量:	783.83
CAS No:	1883545-52-5
分子式:	C₃₇H₅₀F₅N₇O₆
分子量:	783.83

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M10871 MM-102 TFA ≥98% (psaitong)

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包装规格：

100mg in glass bottle

溶解性：

溶于DMSO（≥100mg/mL）

产品描述：

基本信息

产品编号：M10871
产品名称：MM-102 TFA
CAS:	1883545-52-5	储存条件	粉末	-20℃	四年

分子式：	C37H50F5N7O6		溶于液体	-80℃	六个月
分子量：	783.83			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	1.2758mL	6.3789mL	12.7579mL
5mM	0.2552mL	1.2758mL	2.5516mL
10mM	0.1276mL	0.6379mL	1.2758mL

生物活性

产品描述

一种有效的 WDR5/MLL 相互作用抑制剂, WDR5 结合检测中, IC50 =2.4nM, Ki< 1nM。

靶点/IC50

2.4nM (MLL).

体外研究

MM-102 (HMTase Inhibitor IX) inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.MM-102 (TFA), with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay withIC50=0.4-0.9μM.MM-102 (HMTase Inhibitor IX) dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively.MM-102 (HMTase Inhibitor IX) has IC50=25μM in both cell lines and completely inhibits cell growth in these cell lines at 75μM.MM-102 (HMTase Inhibitor IX) effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.

推荐实验方法(仅供参考)

细胞实验:

MV4;11, KOPN8, and K562 cells were cultured in RPMI 1640 medium (ATCC) supplemented with 10% fetal bovine serum and 100 U/L penicillinstreptomycin and incubated at 37℃under 5% CO2.Cells were seeded into 12-well plates for suspension at a density of 5×105 per well (1mL) and treated with either vehicle control (DMSO, 0.2%) or MM-102 (HMTase Inhibitor IX) for 7 days.The medium was changed every 2 days, and compounds were resupplied. The CellTiter-Glo Luminescent Cell Viability Assay kit was used. First, 100μL of the assay reagent was added into each well, and the content was mixed for 2 min on an orbital shaker to induce cell lysis. After 10 min incubation at room temperature, the luminescence was read on a microplate reader.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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