| 中文名称: | YS-49 | ||||
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| 英文名称: | YS-49 | ||||
| 别名: | 1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐 YS49;1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol Hydrobromide | ||||
| CAS No: | 132836-42-1 | 分子式: | C20H20BrNO2 | 分子量: | 386.28 |
| CAS No: | 132836-42-1 | ||||
| 分子式: | C20H20BrNO2 | ||||
| 分子量: | 386.28 | ||||
基本信息
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产品编号： |
V10129 |
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产品名称： |
YS-49 |
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CAS: |
132836-42-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃（储于氮气） |
6个月 |
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分子量： |
386.28 |
-20℃（储于氮气） |
1个月 |
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化学名： |
YS-49;1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.5888mL |
12.9440mL |
25.8880mL |
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5mM |
0.5178mL |
2.5888mL |
5.1776mL |
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10mM |
0.2589mL |
1.2944mL |
2.5888mL |
生物活性
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产品描述 |
一种PI3K/Akt(RhoA的下游靶标)的激活剂，可减少3-甲基胆碱处理的细胞中RhoA/PTEN的激活。YS-49能通过诱导血红素加氧酶(HO-1)来抑制血管紧张素II (Ang II)刺激VSMC细胞的增殖。YS-49是异喹啉化合物生物碱，因能激活心脏β-adrenoceptors而具有强烈的正性肌力作用。 |
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靶点 |
Akt;PI3K;Angiotensin Receptor;Adrenergic Receptor |
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体外研究 |
YS-49 (1-100μM;18 hours;RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ,with IC50 values of 22μM and 30μM,respectively.YS-49 (10-100μM;18 hours;RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Cell Viability Assay |
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Cell Line: |
RAVSMC and RAW 264.7 cells |
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Concentration: |
10μΜ,30μΜ and 100μΜ (RAVSMC cells);1μΜ,10μΜ and 100μM (RAW 264.7 cells) |
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Incubation Time: |
18 hours |
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Result: |
Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ,with IC50 values of 22 and 30μM,respectively. |
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Western Blot Analysis |
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Cell Line: |
RAVSMC and RAW 264.7 cells |
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Concentration: |
10μΜ,30μΜ and 100μΜ |
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Incubation Time: |
18 hours |
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Result: |
Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
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体内研究 |
YS-49 (5mg/kg;intraperitoneal injection;8 hours;male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats,the NOx levels reduce from 86μM to 34μM. |
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Animal Model: |
Male Sprague Dawley rats (250-300g) |
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Dosage: |
5mg/kg |
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Administration: |
Intraperitoneal injection;8 hours |
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Result: |
Serum NOx levels were significantly reduced. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
