| 中文名称: | ZM39923 hydrochloride | ||||
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| 英文名称: | ZM39923 hydrochloride | ||||
| 别名: | 3-[异丙基(苄基)氨基]-1-(2-萘基)-1-丙酮盐酸盐 ZM39923 (hydrochloride);3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochloride | ||||
| CAS No: | 1021868-92-7 | 分子式: | C23H25NO.HCl | 分子量: | 367.91 |
| CAS No: | 1021868-92-7 | ||||
| 分子式: | C23H25NO.HCl | ||||
| 分子量: | 367.91 | ||||
基本信息
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产品编号： |
Z10048 |
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产品名称： |
ZM39923 hydrochloride |
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CAS: |
1021868-92-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
367.91 |
-20℃ |
1个月 |
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化学名： |
1-Propanone,3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-,hydrochloride (1:1) |
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Solubility (25°C)： |
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体外:
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DMSO |
30mg/mL (81.54mM) |
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Ethanol |
8mg/mL (21.74mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.7181mL |
13.5903mL |
27.1806mL |
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5mM |
0.5436mL |
2.7181mL |
5.4361mL |
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10mM |
0.2718mL |
1.3590mL |
2.7181mL |
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50mM |
0.0544mL |
0.2718mL |
0.5436mL |
生物活性
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产品描述 |
一种JAK3抑制剂，pIC50值为7.1;ZM39923 hydrochloride同时可抑制组织型转谷氨酞胺酶(TGM2)的活性，IC50值为10nM。 |
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靶点 |
TGM2 |
JAK3 |
EGFR |
JAK1 |
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10nM |
7.1(pIC50) |
5.6(pIC50) |
4.4(pIC50) |
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体外研究 |
ZM39923 hydrochloride is a JAK3 inhibitor,with a pIC50 of 7.1.ZM39923 (Compound 7) shows weak inhibitory effect on EGFR and JAK1 (pIC50,5.6,4.4,respectively),and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50<5.0).ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10nM,and acts directly on purified TGM2 to inhibit the Ca2+activated form of TGM2.ZM39923 blocks the phosphorylation of JAK3 induced by CCL19,and such an effect is similar to that of CCR7 antibody.ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells. |
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推荐实验方法(仅供参考)
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细胞实验: |
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PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum,penicillin,and streptomycin in an atmosphere of 5% CO2 and 95% air at 37℃.The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
