| 中文名称: | WHI-P97 | ||||
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| 英文名称: | WHI-P97 | ||||
| 别名: | 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉;2,6-二溴-4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚 WHI-P-97;2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | ||||
| CAS No: | 211555-05-4 | 分子式: | C16H13Br2N3O3 | 分子量: | 329.39 |
| CAS No: | 211555-05-4 | ||||
| 分子式: | C16H13Br2N3O3 | ||||
| 分子量: | 329.39 | ||||
基本信息
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产品编号： |
W10039 |
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产品名称： |
WHI-P97 |
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CAS: |
211555-05-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
329.39 |
-20℃ |
1个月 |
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化学名： |
WHI-P 974-(3',5'-Dibromo-4-hydroxyphenyl)amino-6,7-dimethoxyquinazoline |
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Solubility (25°C)： |
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体外:
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DMSO |
8mg/mL (17.57mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1973mL |
10.9866mL |
21.9732mL |
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5mM |
0.4395mL |
2.1973mL |
4.3946mL |
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10mM |
0.2197mL |
1.0987mL |
2.1973mL |
生物活性
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产品描述 |
一种有效的选择性JAK-3抑制剂。WHI-P97在动物模型中有效预防过敏性哮喘的发展。 |
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靶点 |
JAK3 11μM (IC50) |
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体外研究 |
WHI-P97 inhibits the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcεRI crosslinking by >90% at low micromolar concentrations.WHI-P97 (30μM) stantially reduces the IgE/antigen-induced LTC4 release from mast cells. |
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体内研究 |
WHI-P97 is very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5μg/kg to 50mg/kg,and LD10 is not reached at a 50mg/kg dose level when administered as a single i.p.or i.v.bolus dose.WHI-P97 (i.v.injection;40mg/kg;single dose) has an elimination half-life (t1/2) of 58.9 min and systemic clearance (CL) of 891ml/h/kg in CD-1 mice and a t1/2 of 84.2 min and CL of 1513ml/h/kg in BALB/c mice.The values for AUC and Cmax are 107.3μM and 296.7μM,respectively, in CD-1 mice.And the IC50 values are 58.4μM and 212.7μM,respectively, in BALB/c mice.The large volume of distribution are 322ml/kg in CD-1 mice and 415 ml/kg in BALB/c mice.WHI-P97 (intraperitoneal injection;40mg/kg;24 days) prevents ovalbumin-sensitized mice the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion in mice. WHI-P97 inhibits the eosinophil recruitment to the airway lumen after the ovalbumin challenge in a dose-dependent fashion. |
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Animal Model: |
BALB/c mouse model of allergic asthma |
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Dosage: |
40mg/kg |
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Administration: |
intraperitoneal injection;24 days |
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Result: |
Showed promising biological activity in a mouse model of allergic asthma at nontoxic dose levels. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
