| 中文名称: | 缬沙坦 | ||||
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| 英文名称: | Valsartan | ||||
| 别名: | 缬沙坦 CGP 48933 | ||||
| CAS No: | 137862-53-4 | 分子式: | C24H29N5O3 | 分子量: | 435.52 |
| CAS No: | 137862-53-4 | ||||
| 分子式: | C24H29N5O3 | ||||
| 分子量: | 435.52 | ||||
基本信息
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产品编号：V10132 |
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产品名称：Valsartan |
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CAS: |
137862-53-4 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量： |
435.52 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
87mg/mL (199.76mM) |
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Ethanol |
87mg/mL (199.76mM) |
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Water |
Insoluble |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.2961mL |
11.4805mL |
22.9611mL |
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5mM |
0.4592mL |
2.2961mL |
4.5922mL |
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10mM |
0.2296mL |
1.1481mL |
2.2961mL |
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50mM |
0.0459mL |
0.2296mL |
0.4592mL |
生物活性
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产品描述 |
一种血管紧张素 II (angiotensin II) 受体拮抗剂，有潜力用于高血压和心力衰竭的研究。 |
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靶点/IC50 |
angiotensin II receptor |
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体外研究 |
Valsartan (CGP 48933) is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin.Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells.The pretreatment of valsartan results in an inhibition of TLR2 signaling and proinflammatory cytokines.The expression of AGTR1 is up-regulated after alcohol exposure,and is blocked by valsartan pretreatment. |
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体内研究 |
Valsartan (CGP 48933) significantly attenuates the expression of TGF-β/Smad, Hif-1αand fibrosis-related protein in rats after MI.Heart function,infarcted size,wall thickness as well as myocardial vascularization of ischaemic hearts are also significantly improved by valsartan compared with saline and hydralazine.Valsartan partially reverses the effects of high-salt diet on hypertension,cardiac injuries such as fibrosis and inflammatory cell infiltration,and inhibition of aquaporin 1 and angiogenic factors;valsartan alone does not exert such effects.Valsartan is an effective antidepressant/antianxiety reagent and can promote the hippocampal neurogenesis and expression of BDNF.Chronic administration of valsartan (5-40mg/kg/d,p.o.) increases the time spent in the center of the field in OFT and the latency to eat in NSF,reduces the immobility time in both TST and FST,and increases the sucrose preference in SPT. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats: |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
