| 中文名称: | CGP48369 | ||||
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| 英文名称: | CGP48369 | ||||
| CAS No: | 135689-23-5 | 分子式: | C26H30N6O | 分子量: | 442.56 |
| CAS No: | 135689-23-5 | ||||
| 分子式: | C26H30N6O | ||||
| 分子量: | 442.56 | ||||
基本信息
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产品编号： |
C110984 |
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产品名称： |
CGP48369 |
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CAS: |
135689-23-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
442.56 |
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化学名： |
2,6-dibutyl-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1H-pyrimidin-4-one |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
是血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，用于研究抗高血压疾病。 |
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靶点 |
Angiotensin Receptor |
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体外研究 |
CGP 48369 binds to the ATl receptor (IC50 1.8 nM in vascular smooth musc1e cells, VSMC) and inhibits AII-induced contraction in rabbit aorta (IC50 8.7 nM). |
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体内研究 |
CGP48369 (10mg/kg/day p.o.) decreases BP in two-kidney/one-clip renal hypertensive rats for at least 24h.In arteries with endothelium,contractions induced by AII 3×10-8 M do not differ in untreated spontaneously hypertensive rats (SHR) and WKY.All evoked significantly smaller contractions in SHR treated with CGP 48369 than in the other treated SHR.Antihypertensive treatment with benazepril or nifedipine, and to a lesser extent with CGP 48369,increases the sensitivity (pD2-va1ue) to intraluminal ACh.In arteries without endothelium,sensitivity to NE is identical in all groups,whereas maximal response in CGP 48369-treated SHR and in nifedipine treated SHR is slightly greater as compared with that in WKY.In SHR,antihypertensive therapy with either benazepril HCl,CGP 48369,valsartan,or nifedipine (each 10mg/kg/d for 8 weeks) significantly increase endothelium-dependent relaxations evoked by acetylcholine. |
推荐实验方法(仅供参考)
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动物实验: |
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Male Wistar-Kyoto rats (WKY) and SHR aged 7 weeks are used in the assay.All rats are maintained on standard chow with free access to drinking water and used for experiments at age 15 weeks.SHR are randomly assigned 4 groups:All 4 groups are gavaged;in 3 of the 4,either CGP 48369,benazepril,or nifedipine (all 10mg/kg/day p.o.) is administered for 8 weeks until the day ofthe experiment (age 15 weeks).All drugs are administered only once a day.Rats are studied in randomized order in a single-blinded design.BP is measured by the tail-cuff method 18-20h after the last administration.Body weight and heart rate (HR) do not differ at the end of the treatment period in the four groups.On the day of the experiment,rats are anesthetized with pentobarbital (40mg/kg intraperitoneally,i.p.) and the mesenterium is removed and placed in cold (40℃) Krebs-Ringer bicarbonate solution (in mM):NaCl 118.6,KCl 4.8,CaCl2 2.5,MgS04 1.2,KH2P04 1.2,NaHC03 25.1,edetate calcium disodium 0.026,glucose 10.1 (Krebs solution). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
