| 中文名称: | (R)-Lisofylline | ||||
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| 英文名称: | (R)-Lisofylline | ||||
| 别名: | (R)-Lisofylline (R)-Lisophylline | ||||
| CAS No: | 100324-81-0 | 分子式: | C13H20N4O3 | 分子量: | 280.32 |
| CAS No: | 100324-81-0 | ||||
| 分子式: | C13H20N4O3 | ||||
| 分子量: | 280.32 | ||||
基本信息
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产品编号： |
R10353 |
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产品名称： |
(R)-Lisofylline |
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CAS: |
100324-81-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(氮气保存) |
6个月 |
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分子量： |
280.32 |
-20℃(氮气保存) |
1个月 |
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化学名： |
3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种Pentoxifylline代谢产物的(R)-型对映体，具有抗炎特性。一种溶血磷脂酸酰基转移酶(lysophosphatidicacidacyltransferase)抑制剂，IC50为0.6µM，可中断IL-12信号介导的STAT4激活。(R)-Lisofylline可用于1型糖尿病，自身免疫性疾病的研究。 |
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靶点 |
IC50:0.6µM (Lysophosphatidic acid acyltransferase) STAT4 |
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体外研究 |
(R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro. |
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体内研究 |
(R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells,suppresses IFN-γ production,the onset of diabetes,and macrophage infiltration into islets from NOD mice,as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test.(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling.(R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice.(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs.In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs.(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or Escherichia coli. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
