Colivelin - CAS:867021-83-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Colivelin
英文名称:	Colivelin
别名:	Colivelin Colivelin
CAS No:	867021-83-8	分子式:	C₁₁₉H₂₀₆N₃₂O₃₅	分子量:	2645.1
CAS No:	867021-83-8
分子式:	C₁₁₉H₂₀₆N₃₂O₃₅
分子量:	2645.1

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C11136 Colivelin (psaitong)

相关产品

包装规格：

500ug in glass bottle

产品描述：

基本信息

产品编号：	C11136
产品名称：	Colivelin
CAS:	867021-83-8	储存条件	粉末	-20℃	四年

分子式：	C119H206N32O35		溶于液体	-80℃	6个月
分子量：	2645.10			-20℃	1个月
化学名：
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water	100mg/mL (37.8mM)
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	0.3781mL	1.8903mL	3.7806mL
5mM	0.0756mL	0.3781mL	0.7561mL
10mM	0.0378mL	0.1890mL	0.3781mL

生物活性

产品描述	一种具有大脑通透性的神经保护肽(neuroprotectivepeptide)，是STAT3的有效激活剂。Coliveli通过激活STAT3在体外抑制神经元死亡。Colivelin对神经毒性、Aβ沉积,神经元细胞凋亡,在神经退行性疾病显示出长期有利的影响。Colivelin具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。
靶点	STAT3		Amyloid-β
体外研究	Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm,and keep its neuroprotective action at or above the levels of 1nm.Colivelin-induced neuroprotection occurs via two neuroprotective pathways:one mediated by Ca2+/calmodulin-dependent protein kinase IV,triggered by ADNF,and one mediated by signal transducer and activator of transcription 3,triggered by HN.Colivelin reverses caspase3,Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition.Colivelin (50µg/mL,4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells. Western Blot Analysis
	Cell Line:	BV-2 cells.
	Concentration:	50µg/mL.
	Incubation Time:	4 hours.
	Result:	Increased p-STAT3 levels.
	Cell Viability Assay
	Cell Line:	KYSE70 and TE8 cells.
	Concentration:	0.5μM.
	Incubation Time:	1 hour (followed by CYT-Rx20 treatment)
	Result:	Sgnificantly suppressed the viability in KYSE70 and TE8 cells.
体内研究	Colivelin (intracerebroventricular administration;10 pmol/3μl;3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42,in addition,it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42.Colivelin (intraperitoneal administration;1.4,7,or 35nM/0.21mL;on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit.Colivelin (intraperitoneal injection;1mg/kg;14 days) results in improved motor and cognitive function with time by performance of mNSS,rotarod,and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO.
	Animal Model:	CD-1 mice
	Dosage:	10 pmol/3μl
	Administration:	Intracerebroventricular administration
	Result:	Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.

	Animal Model:	C57 mice
	Dosage:	1.4,7,or 35nM/0.21mL
	Administration:	Intraperitoneal administration
	Result:	Protected against cholinotoxin-induced amnesia in mice.

	Animal Model:	Male C57BL/6 mice
	Dosage:	1mg/kg
	Administration:	Intraperitoneal administration
	Result:	Protected against ischemic brain injury,and improves neurological outcomes

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果