中文名称: | Butaprost | ||||
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英文名称: | Butaprost | ||||
别名: | 布他前列素 methyl 7-[3-hydroxy-2-[4-hydroxy-4-(1-propylcyclobutyl)but-1-enyl]-5-oxocyclopentyl]heptanoate | ||||
CAS No: | 69685-22-9 | 分子式: | C24H40O5 | 分子量: | 408.57 |
CAS No: | 69685-22-9 | ||||
分子式: | C24H40O5 | ||||
分子量: | 408.57 |
基本信息
产品编号: |
B11536 |
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产品名称: |
Butaprost |
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CAS: |
69685-22-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
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分子量: |
408.57 |
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化学名: |
Methyl 7-[3-hydroxy-2-[4-hydroxy-4-(1-propylcyclobutyl)but-1-enyl]-5-oxocyclopentyl]heptanoate |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种选择性前列腺素E受体(EP2)激动剂,对鼠类EP2受体的EC50值为33nM,Ki值为2.4μM。Butaprost对鼠类EP1,EP3和EP4受体的活性较低。Butaprost通过阻碍TGF-β/Smad2信号传导来减轻纤维化。 |
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靶点 |
m-EP2 receptor 2400nM (Ki) |
m-EP2 receptor 33nM (EC50) |
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体外研究 |
Butaprost (1-100nM;0.5-24 hours) induces about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells in a dose-and time-dependent.Butaprost upregulated Nur77 gene expression through the PKC pathway.Butaprost (50μM;24 hours) reduces TGF-β-induced fibronectin (FN) expression,Smad2 phosphorylation and epithelialmesenchymal transition in Madin-Darby Canine Kidney (MDCK) cells. Western Blot Analysis |
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Cell Line: |
HEK 293/EBNA cells stably expressing the human EP2 receptor (hEP2-HEK 293/EBNA cells) |
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Concentration: |
1nM,10nM,100nM |
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Incubation Time: |
0.5 hours,1 hours,6 hours,24 hours |
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Result: |
Induced about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells. |
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体内研究 |
Butaprost (1-4mg/kg;intraperitoneal injection;twice daily;for 7 days) treatment attenuates the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery,as illustrated by a reduction in the gene and protein expression of α-smooth muscle actin, fibronectin and collagen 1A1. |
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Animal Model: |
Male C57BL/6 mice (8 weeks of age;21g) bearing unilateral ureteral obstruction surgery |
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Dosage: |
1mg/kg,2mg/kg,4mg/kg |
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Administration: |
Intraperitoneal injection;twice daily;for 7 days |
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Result: |
Attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )