基本信息
产品编号: |
R10280 |
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产品名称: |
Reticuline |
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CAS: |
485-19-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
329.39 |
-20℃ |
1个月 |
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化学名: |
(S)-1,2,3,4-TETRAHYDRO-1-[(3-HYDROXY-4-METHOXYPHENYL)METHYL]-6-METHOXY-2-METHYLISOQUINOLIN-7-OL |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
通过JAK2/STAT3和NF-κB信号通路显示抗炎作用。Reticuline还可抑制TNF-α和IL-6的mRNA表达,并降低JAK2和STAT3的磷酸化水平Reticuline具有心血管作用。 |
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靶点 |
JAK2 |
STAT3 |
NF-κB |
体外研究 |
Reticuline (3μM,30μM,300μM,900μM and 1.5mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1μM),KCl (80mM) and KCl (30mM),(IC50=40±10,240±40 and 300±40μM,respectively) in isolated rat aortic rings with intact endothelium.Reticuline (3μM,30μM,300μM,900μM and 1.5mM) antagonizes CaCl2-induced contractions,and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM),but not those induced by Caffeine (20mM). |
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体内研究 |
Reticuline (5,10 and 20mg/kg,i.v.,randomly) injections produced an intense hypotension in normotensive rats.The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of:1) muscarinic stimulation and NOS activation in the vascular endothelium,2) voltage-dependent Ca2+ channel blockade and/or 3) inhibition of Ca2+ release from norepinephrine-sensitive intracellular stores. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )