LM22A-4 - CAS:37988-18-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	LM22A-4
英文名称:	LM22A-4
别名:	1-N,3-N,5-N-三(2-羟乙基)苯-1,3,5-三酰胺;N,N',N''-三(2-羟基乙基)-1,3,5-苯三甲酰胺 N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
CAS No:	37988-18-4	分子式:	C₁₅H₂₁N₃O₆	分子量:	339.34
CAS No:	37988-18-4
分子式:	C₁₅H₂₁N₃O₆
分子量:	339.34

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L11046 LM22A-4 ≥98% (psaitong)

相关产品

包装规格：

5mg 10mg 25mg 50mg 100mg in glass bottle

溶解性：

溶于水(≥5mg/mL）

产品描述：

基本信息

产品编号：L11046

产品名称：LM22A-4

CAS:

37988-18-4

储存条件

粉末

-20℃

四年

分子式：

C15H21N3O6

溶于液体

-80℃

六个月

分子量

339.34

-20℃

一个月

化学名：

Solubility (25°C)

体外

DMSO

68mg/mL (200.38mM)

Ethanol

68mg/mL (200.38mM)

Water

Insoluble

体内（现配现用）

＜1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.9469mL	14.7345mL	29.4690mL
5mM	0.5894mL	2.9469mL	5.8938mL
10mM	0.2947mL	1.4734mL	2.9469mL
50mM	0.0589mL	0.2947mL	0.5894mL

生物活性

产品描述	一种特异性的 tyrosine kinase receptor B 激动剂，常用于神经系统疾病研究。
靶点/IC50	TrkB
体外研究	LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a timedependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media.
体内研究	M22A-4 (10mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration(10mg/kg)significantly improves the neurological scores compared with those of the solvent-treated animals.

推荐实验方法(仅供参考)

动物实验:

ICR mice are randomly divided into five groups: sham treatment, spinal cord injury, spinal cord injury combined with solvent treatment, spinal cord injury combined with LM22A-4 treatment (10mg/kg), and spinal cord injury combined with LM22A-4 treatment (15mg/kg), with each group containing 26 animals. Preparation of the mouse SCI model is based on a previous study and on a protocol employed by this group. Briefly, a mouse is anesthetized via the administration of chloral hydrate (4mg/kg) before a 3-cm incision is introduced on its back. T7-T11 vertebrae are exposed under a surgical microscope before the laminae are removed with a vascular clip to fully expose the spinal cord. The spinal cord is clamped with the vascular clip for 1 minute with a force of 10g. The animal is then subjected to complete staunching of the bleeding, and the incised dorsal muscle and skin are sutured. Mice from the control group undergo laminectomy, full exposure of the spinal cord, and subsequent suturing, but without aortic clamping. After the surgery, the mice are placed on a warm blanket until fully awake and are then housed in cages accommodating a normal diet. After the SCI treatment, 14 mice are sacrificed to enable molecular and histological examinations; the other 14 mice are allowed to live for 20 days for neurological scoring and are sacrificed on day 20 via cervical dislocation.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果