中文名称: | AZ-23 | ||||
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英文名称: | AZ-23 | ||||
别名: | 5-Chloro-N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | ||||
CAS No: | 915720-21-7 | 分子式: | C17H19ClFN7O | 分子量: | 391.83 |
CAS No: | 915720-21-7 | ||||
分子式: | C17H19ClFN7O | ||||
分子量: | 391.83 |
基本信息
产品编号:A12793 |
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产品名称:AZ-23 |
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CAS: |
915720-21-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
391.83 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.5521mL |
12.7606mL |
25.5213mL |
5mM |
0.5104mL |
2.5521mL |
5.1043mL |
10mM |
0.2552mL |
1.2761mL |
2.5521mL |
生物活性
产品描述 |
一种ATP-竞争型,有口服活性的Trk激酶 A/B/C抑制剂。 |
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靶点/IC50 |
TrkA 2nM (IC50) |
TrkB 8nM (IC50) |
体外研究 |
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines. |
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体内研究 |
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma. |
推荐实验方法(仅供参考)
细胞实验: |
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Exponentially growing TF-1 cells are treated with various concentrations of AZ-23 and then incubated for an additional 72h at 37°C in either growth or basal medium plus 100ng/mL NGF. Cell proliferation is measured using MTS solution. |
动物实验: |
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Mice Tumor-bearing mice are given a single, oral dose of compound and individual mice are sacrificed at various time points postdose (2,6,16, or 24 hours). Tumors are excised and homogenized and the resulting tumor lysates are analyzed using an ELISA for pTrkA. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )