中文名称: | Losartan Carboxylic Acid | ||||
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英文名称: | Losartan Carboxylic Acid | ||||
别名: | 氯沙坦羧酸 E-3174; EXP-3174 | ||||
CAS No: | 124750-92-1 | 分子式: | C22H21ClN6O2 | 分子量: | 436.89 |
CAS No: | 124750-92-1 | ||||
分子式: | C22H21ClN6O2 | ||||
分子量: | 436.89 |
基本信息
产品编号: |
L10420 |
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产品名称: |
Losartan Carboxylic Acid |
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CAS: |
124750-92-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
436.89 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
87mg/mL (199.13mM) |
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Ethanol |
87mg/mL (199.13mM) |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.2889mL |
11.4445mL |
22.8891mL |
5mM |
0.4578mL |
2.2889mL |
4.5778mL |
10mM |
0.2289mL |
1.1445mL |
2.2889mL |
50mM |
0.0458mL |
0.2289mL |
0.4578mL |
生物活性
产品描述 |
一种Losartan 的活性羧酸代谢产物,是血管紧张素 Ⅱ 受体 1 型 (AT1) 拮抗剂。对大鼠 AT1B/AT1A 和人 AT1 的 Ki 值分别为 0.97、0.57、0.67nM。 |
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靶点 |
binding of [125I]-angiotensin II to VSMC |
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1.1nM |
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体外研究 |
The specific binding of [125I]-angiotensin II to VSMC is inhibited by Losartan Carboxylic Acid (E-3174) with an IC50 of 1.1nM.Losartan Carboxylic Acid abolishes the angiotensin II-induced formation of inositolphosphates in VSMC.Losartan Carboxylic Acid inhibits the angiotensin II-induced elevation of intracellular cytosolic Ca2+concentration with an IC50 of 5nM.Losartan Carboxylic Acid is more effective than losartan in blocking the angiotensin II-induced increase in Egr-1 mRNA.Losartan Carboxylic Acid inhibits the angiotensin II-induced cell protein synthesis with an IC50 of 3nM. |
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体内研究 |
Losartan Carboxylic Acid (E-3174) (0.1mg/kg;i.v. followed by 0.02mg/kg/h for 5.5h) induces a similar level of inhibition (87±4%) of the pressor responses to angiotensin I.Intravenous Losartan Carboxylic Acid (0.1mg/kg+0.01mg/kg/min) is infused in anesthetized dogs with recent (8.1±0.4 days) anterior myocardial infarction.Electrolytic injury of the left circumflex coronary artery to induce thrombotic occlusion and posterolateral ischemia is initiated 1h after the start of treatment. |
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Animal Model: |
Mongrel dogs of either sex, weighing 15-25kg |
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Dosage: |
0.1mg/kg (followed by 0.02mg/kg/h) |
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Administration: |
i.v.for 5.5 hours |
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Result: |
The pressor response was reduced by 87±4%. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )