中文名称: | 呋塞米钠 | ||||
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英文名称: | Furosemide sodium | ||||
别名: | 呋塞米钠 Furosemidesodium | ||||
CAS No: | 41733-55-5 | 分子式: | C12H10ClN2NaO5S | 分子量: | 352.73 |
CAS No: | 41733-55-5 | ||||
分子式: | C12H10ClN2NaO5S | ||||
分子量: | 352.73 |
基本信息
产品编号: |
F10430 |
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产品名称: |
Furosemide sodium |
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CAS: |
41733-55-5 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
352.73 |
-20℃ |
1个月 |
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化学名: |
sodium;4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoate |
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Solubility (25°C): |
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体外:
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DMSO |
71mg/mL (201.28mM) |
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Ethanol |
Insoluble |
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Water |
71mg/mL (201.28mM) |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.8350mL |
14.1751mL |
28.3503mL |
5mM |
0.5670mL |
2.8350mL |
5.6701mL |
10mM |
0.2835mL |
1.4175mL |
2.8350mL |
生物活性
产品描述 |
一种Na+/K+/2Cl-(NKCC),NKCC1和NKCC2共转运蛋白的有效的和具有口服活性抑制剂。Furosemidesodium也是GABAA受体拮抗剂,对含α6受体的选择性是含α1受体的100倍。Furosemidesodium用作利尿试剂,用于充血性心力衰竭,高血压和水肿的研究。 |
靶点 |
IC50:NKCC1 and NKCC2 IC50:GABAA receptors |
体外研究 |
Furosemide sodium (500µM;72-96 hours) significantly changes the proliferation rates in MKN45 cells (the poorly differentiated human gastric adenocarcinoma cell line).however,it has no effects on MKN28 cells (the moderately differentiated human gastric adenocarcinoma cell line).The growth rate of MKN45 cells is larger than that of MKN28 cells.Furosemide sodium (10µM,30µM,100µM;45 min exposure)significantly decreases cation channel activity and [Ca(2+)](i) in human erythrocytes drawn from healthy individuals.Tert-butylhydroperoxide similarly enhances the non-selective cation channels activity,increases [Ca(2+)](i) and triggered cell membrane scrambling,however,the effects is significantly blunted by Furosemide sodium again. |
体内研究 |
Furosemide sodium (intraperitoneal injection;100mg/kg;single dose) is injected after kanamycin (KM) (1000mg/kg) to creat a deaf mouse model in C57BL/6 mouse.After injection,hearing loss and cochlear hair cell damage are evaluated on day 1,day 2 and day 3,respectively.The hearing is markedly deteriorated even from the next day (Day-1 group),OHCs (outer hair cell) morphology of apical,middle and basal turns are disorganized in mice on day3. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )