DC260126 - CAS:346692-04-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	DC260126
英文名称:	DC 260126
别名:	DC260126 N-(4-Butylphenyl)-4-fluoro-benzenesulfonamide
CAS No:	346692-04-4	分子式:	C₁₆H₁₈FNO₂S	分子量:	307.38
CAS No:	346692-04-4
分子式:	C₁₆H₁₈FNO₂S
分子量:	307.38
MDL:	MFCD00784423

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF) 点击下载技术规格说明书(PDF)

D10050 DC260126 ≥98%(HPLC) (psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO（20mg/ml）

产品描述：

基本信息

产品编号：	D10050
产品名称：	DC 260126
CAS:	346692-04-4	储存条件	粉末	-20℃	四年

分子式：	C16H18FNO2S		溶于液体	-80℃	6个月
分子量：	307.38			-20℃	1个月
化学名：	N-(4-Butylphenyl)-4-fluoro-benzenesulfonamide
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.2533mL	16.2665mL	32.5330mL
5mM	0.6507mL	3.2533mL	6.5066mL
10mM	0.3253mL	1.6267mL	3.2533mL

生物活性

产品描述

一种FFA1（GPR40）选择性拮抗剂。在表达FO 1的CHO细胞中，DC260126阻断亚油酸诱导的Ca2+升高和ERK磷酸化（IC50＝6028μm），以及棕榈酸增强葡萄糖刺激的胰岛素分泌。DC260126阻断棕榈酸诱导的MN6β细胞的ER应激和凋亡。

靶点

GPR40

Apoptosis

体外研究

DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells,suppresses palmitic acid potentiated glucose-stimulated insulin secretion,and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.

推荐实验方法(仅供参考)

动物实验:

Mice

Male C57BL/KsJ-Lepdb (db/db) are maintained in a 12h light-dark cycle at a temperature of 23℃ with free access to water and regular chow diet.To investigate the dose-dependent effect of DC260126,nine-week-old db/db male mice are divided into four groups (n=6/group).Mice are give vehicle (5% DMSO in PBS) or DC260126 (3,10,30mg/kg) once daily by tail vein injection for 5 days.At day 5,each group of mice are fasted for 6 h and blood samples are collected from orbital venous plexus and centrifuged for serum separation.Then the concentration of serum insulin level is measured by ELISA kit.For long term experiments,six-week-old obese db/db male mice are divided into two groups (n=8/group) and given vehicle (5% DMSO in PBS) or DC260126 (10mg/kg) once daily by tail vein injection for 24 days,respectively.

Rats

Female obese (fa/fa) Zucker rats are maintained in a 12:12 light-dark cycle with free access to water and a high-fat diet containing 15% fat,1% cholesterol,0.5% sodium cholate and 15% sucrose,except when fasted before some experiments.Rats at 8 weeks of age are divided into two groups (n=6/group) on the basis of body weight.Rats are injected intraperitoneally once daily with vehicle (propylene glycol) or DC260126 (6mg/kg) for 8 weeks. Food intake and body weight are monitored periodically. At the end of the experimental period,mice are fasted for 12h and then blood is collected.Liver,renal,adipose tissues are rapidly excised and weighed.Liver samples are snap frozen in liquid nitrogen and stored at -80℃ for western blotting analysis.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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