AP20187 - CAS:195514-80-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	AP20187
英文名称:	AP20187
别名:	B/B Homodimerizer
CAS No:	195514-80-8	分子式:	C₈₂H₁₀₇N₅O₂₀	分子量:	1482.75
CAS No:	195514-80-8
分子式:	C₈₂H₁₀₇N₅O₂₀
分子量:	1482.75

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

A11601 AP20187 ≥98% (psaitong)

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包装规格：

1mg in glass bottle

溶解性：

溶于DMSO（≥57mg/mL）

产品描述：

基本信息

产品编号：A11601
产品名称：AP20187
CAS:	195514-80-8	储存条件	粉末	-20℃	四年

分子式：	C82H107N5O20		溶于液体	-80℃	六个月
分子量	1482.75			-20℃	一个月
化学名：	[(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[[2-[[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]methyl]-3-(dimethylamino)propyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
Solubility (25°C)	体外	DMSO	≥57mg/mL (38.44mM)
		Ethanol	100mg/mL (67.44mM; Need ultrasonic)
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	0.6744mL	3.3721mL	6.7442mL
5mM	0.1349mL	0.6744mL	1.3488mL
10mM	0.0674mL	0.3372mL	0.6744mL

生物活性

产品描述	一种细胞渗透性分子，使 FK506 结合蛋白 (FKBP) 二聚化，启动生物信号传导级联反应和基因表达，或破坏蛋白-蛋白之间相互作用。
靶点/IC₅₀	FKBP homodimerizer
体外研究	When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100nM), ro-iCaspase-9 levels are significantly reduced,and the smaller processed active caspase-9 becomes apparent.
体内研究	Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2EPERK mice

推荐实验方法(仅供参考)

细胞实验：

Cell Assay

For the in vitro study, 16 h after ADV infection, cells are treated with R1881 (10nM), AP20187 (B/B Homodimerizer) (10nM),both, or neither for 8h. Cells are then rinsed with PBS and fixed with 4% paraformaldehyde for 1h at room temperature.After rinsing with PBS, cells are incubated in ice-cold permeabilization solution (0.1% Triton X-100, 0.1% sodium citrate) for 2 min at 0°C. Cells are rinsed with PBS and stained with TUNEL reaction mixture for 60 min at 37°C. After another PBS wash,cells are incubated with Converter-AP for 30min at 37°C. Cells are rinsed and incubated with substrate 5-bromo-4-chloro-3- indolyl phosphate/nitroblue tetrazolium for 30min. After a final PBS rinse (repeated twice), cells are microphotographed.

动物实验:

Animal Administration

To activate the transgene Fv2E-PERK in oligodendrocytes, PLP/Fv2E-PERK transgenic mice are given intraperitoneal injections of AP20187 (B/B Homodimerizer) daily at a dose of 0.5mg/kg, 2mg/kg, or 5mg/kg. Lyophilized AP20187 (B/B Homodimerizer) is dissolved in 100% ethanol at a concentration of 62.5mg/mL stock solution and stored at −20°C. Injection solutions consist of 4% ethanol, 10% PEG-400, and 2% Tween-20 in water. The transgenic mice receiving only the vehicle(4% ethanol, 10% PEG-400, 2% Tween-20 in water) served as controls.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果