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Anti-infection(抗感染)

RSV HCV Influenza Virus Parasite Bacterial(细菌) HBV Fungal(真菌) HSV HIV Virus Protease SARS-CoV CMV Enterovirus Reverse Transcriptase

Protein Tyrosine Kinase/RTK(蛋白酪氨酸激酶/RTK)

EGFR VEGFR BTK SRC Trk(原肌球蛋白受体激酶) PDGFR(血小板衍生生长因子受体) ALK(间变性淋巴瘤激酶) Bcr-Abl c-Fms c-Kit c-Met/HGFR PKA(蛋白激酶A) FAK FGFR TAM Receptor FLT3 IRAK Insulin Receptor(胰岛素受体) IGF-1R Syk RET DYRK Ephrin Receptor Itk

Apoptosis(细胞凋亡)

IAP Bcl-2 Family TNF Receptor MDM-2/p53 Ferroptosis c-Myc RIP kinase Apoptosis Caspase PKD Survivin Thymidylate Synthase 超氧化物歧化酶(SOD)

Autophagy(自噬)

FKBP LRRK2 Autophagy Mitophagy ULK

Cell Cycle/DNA Damage(细胞周期/DNA损伤)

DNA/RNA合成 PARP HSP(热休克蛋白) Sirtuin ROCK p97 PLK(Polo-like Kinase) Topoisomerase(拓扑异构酶) PERK Antifolate Casein Kinase(酪蛋白激酶) ATM/ATR HDAC(组蛋白脱乙酰基酶) Deubiquitinase(DUB) Chk(Checkpoint Kinase) Aurora Kinase RAD51 TOPK Wee1 Nucleoside Antimetabolite/Analog SRPK IRE1 PPAR CDK G-quadruplex Eukaryotic Initiation Factor Mps1 DNA-PK APC DNA Alkylator/Crosslinker Haspin Kinase PAK

Cytoskeleton(细胞骨架)

Myosin(肌球蛋白) Arp2/3 Complex Kinesin Dynamin inhibitor Microtubule/Tubulin Gap Junction Protein Integrin

Epigenetics(表观遗传学)

Histone Acetyltransferase(组蛋白乙酰转移酶) Histone Methyltransferase(组蛋白甲基转移酶) PKC(蛋白激酶C) Epigenetic Reader Domain AMPK(腺苷酸激活蛋白激酶) Histone demethylase(组蛋白去甲基化酶) DNA Methyltransferase(DNA甲基转移酶) MicroRNA Protein Arginine Deiminase

GPCR/G Protein

Prostaglandin Receptor(前列腺素受体) mAChR Adrenergic Receptor(肾上腺素能受体) Sigma Receptor GHSR Histamine Receptor(组胺受体) Angiotensin Receptor(血管紧张素受体) Adiponectin Receptor(脂联素受体) Bombesin Receptor(蛙皮素受体) Ras Glucocorticoid Receptor(糖皮质激素受体) Cannabinoid Receptor Adenylate Cyclase(腺苷酸环化酶) GPR40 Neurokinin Receptor GPR139 Dopamine Receptor(多巴胺受体) CCR Leukotriene Receptor(白三烯受体) CXCR Melatonin Receptor(褪黑素受体) Neuropeptide Y Receptor LPL Receptor mGluR Adenosine Receptor(腺苷受体) P2Y PAR(Protease-Activated Receptor) GPCR19 GPR119 GPR84 Urotensin Receptor GPR120 Endothelin Receptor Opioid Receptor CaSR CGRP Receptor Cholecystokinin Receptor CRFR EBI2/GPR183 MCHR1 GPR55 Melanocortin Receptor Orexin Receptor Somatostatin Receptor GCGR G protein-coupled Bile Acid Receptor 1 GnRH Receptor 食欲素受体

Immunology/Inflammation(免疫学/炎症)

COX Interleukin Related SIK(Salt-inducible Kinase) Complement System Aryl Hydrocarbon Receptor(芳烃受体) TLR(Toll-like Receptor) NLR(NOD-like Receptor) PGE synthase SPHK PD-1/PD-L1 Thrombopoietin Receptor NOD-like Receptor (NLR) Immunology/Inflammation Cyclic GMP-AMP Synthase FLAP Galectin IFNAR MyD88 NO Synthase STING CD73

JAK/STAT Signaling

Pim STAT JAK

MAPK/ERK Pathway

MAP3K MEK p38 MAPK JNK RAF MNK ERK(细胞外调节蛋白激酶) KLF MAPKAPK2 Mixed Lineage Kinase RSK

Membrane Transporter/Ion Channel(膜转运/离子通道)

CFTR Sodium Channel(钠通道) Chloride Channel Calcium Channel(钙通道) NKCC SGLT Na+/K+ ATPase TRP Channel GABA Receptor nAChR iGluR (离子型谷甘酸受体) Na+/Ca2+ Exchanger Potassium Channel(钾通道) URAT1 BCRP CRAC Channel Proton Pump P2X Receptor Na+/HCO3- Cotransporter Monoamine Transporter ATP Synthase P-glycoprotein EAAT2 GLUT GlyT HCN Channel CRM1

Metabolic Enzyme/Protease(代谢酶/蛋白酶)

PDE(Phosphodiesterase) HMGCR(HMG-CoA Reductase) RAR/RXR Ser/Thr Protease Carbonic Anhydrase MMP PGC-1α ROR Dipeptidyl Peptidase Cathepsin Glutathione Peroxidase SCD(Stearoyl-CoA Desaturase) Nampt NEDD8-activating Enzyme Dopamine β-hydroxylase FXR E1/E2/E3 Enzyme Proteasome inhibitor Pyruvate Kinase(丙酮酸激酶) NADPH Oxidase Aminopeptidase(氨基肽酶) Phosphatase Xanthine Oxidase(黄嘌呤氧化酶) IDO HIF/HIF Prolyl-Hydroxylase LXR ROS(Reactive Oxygen Species) Drug Metabolite Endogenous Metabolite ATP Citrate Lyase(ATP柠檬酸裂解酶) FAAH(脂肪酸酰胺水解酶) IDH(异柠檬酸脱氢酶) Acyltransferase Phospholipase(磷脂酶) 前列腺素D合成酶(PGDS) 乙醛脱氢酶(ALDH) ATGL(脂肪甘油三酯脂酶) Factor Xa(凝血因子Xa) Lipoxygenase Gutathione S-transferase Enolase HIV Protease Acetyl-CoA Carboxylase PAI-1 Phosphatase Inhibitor Thrombin COMT Neprilysin Glucokinase Fatty Acid Synthase Dihydroorotate Dehydrogenase CETP Adenosine Deaminase ACE Glutaminase Mitochondrial Metabolism HIV Integrase Aldose Reductase Lactate Dehydrogenase Mineralocorticoid Receptor Aminoacyl-tRNA Synthetase 5 alpha Reductase Cytochrome P450 Epoxide Hydrolase FABP FASN HMGCR MAGL PDHK Carboxypeptidase Elastase Tryptophan Hydroxylase Phosphoglycerate Dehydrogenase (PHGDH)

Neuronal Signaling(神经信号通路)

Amyloid-β γ-secretase β-secretase CaMK Dopamine Transporter 5-HT Receptor(5-羟色胺受体) AChE Monoamine Oxidase Serotonin Transporter

NF-κB信号通路

IKK NF-κB Keap1-Nrf2 活性氧分子

PI3K/Akt/mTOR

AKT mTOR PI3K(胞内磷脂酰肌醇激酶) GSK-3 PDK-1 PIKfyve PI4K MELK PTEN

PROTAC降解

Ligand for E3 Ligase(E3连接酶配体) PROTAC PROTAC Linker SNIPER

Stem Cell/Wnt

YAP Notch Hedgehog Wnt Smo Oct3/4 Hippo (MST) Gli Porcupine sFRP-1

TGF-beta/Smad(信号通路)

TGF-beta/Smad TGF-β Receptor