| 中文名称: | (S)-UFR2709 | ||||
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| 英文名称: | (S)-UFR2709 | ||||
| 别名: | (S)-UFR2709 (S)-UFR2709 | ||||
| CAS No: | 1431628-22-6 | 分子式: | C13H17NO2 | 分子量: | 219.28 |
| CAS No: | 1431628-22-6 | ||||
| 分子式: | C13H17NO2 | ||||
| 分子量: | 219.28 | ||||
基本信息
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产品编号： |
U10112 |
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产品名称： |
(S)-UFR2709 |
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CAS: |
1431628-22-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
一年 |
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分子量： |
219.28 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种竞争性的nAChR拮抗剂，并显示出较强的亲和力，对α4β2 nAChR的亲和力比对α7 nAChR的高。(S)-UFR2709在偏好酒精的老鼠中减少焦虑，并且可以减少其酒精摄入和对酒精偏好。(S)-UFR2709是抗焦虑试剂，可用于研究尼古丁成瘾。 |
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靶点 |
nAChR |
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体外研究 |
Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels,which is a molecular target for the treatment of alcohol abuse and dependence. |
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体内研究 |
(S)-UFR2709 (50-100μg/ml;3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test,and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s,respectively at 50 and 100μg/ml.(S)-UFR2709 (50-100μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit,but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish.(S)-UFR2709 (intraperitoneal injection;1-10mg/kg;daily;17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner.The most effective dose of UFR2709 is 2.5mg/kg,it induces a 56% reduction in alcohol consumption.(S)-UFR2709 does not affect the weight or locomotor activity of the rats. |
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Animal Model: |
High-alcohol-drinking UChB rats |
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Dosage: |
10mg/kg,5mg/kg,2.5mg/kg,or 1mg/kg |
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Administration: |
Intraperitoneal injection;1-10mg/kg;daily;17 days |
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Result: |
Did not affect the weight or locomotor activity and reduced ethanol consumption and preference. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
