| 中文名称: | Saredutant | ||||
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| 英文名称: | Saredutant | ||||
| 别名: | 沙瑞度坦 SR 48968; SR 48968C; (S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide | ||||
| CAS No: | 142001-63-6 | 分子式: | C31H35Cl2N3O2 | 分子量: | 552.53 |
| CAS No: | 142001-63-6 | ||||
| 分子式: | C31H35Cl2N3O2 | ||||
| 分子量: | 552.53 | ||||
基本信息
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产品编号： |
S80006 |
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产品名称： |
Saredutant |
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CAS: |
142001-63-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
552.53 |
-20℃ |
1个月 |
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化学名： |
(S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.8099mL |
9.0493mL |
18.0986mL |
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5mM |
0.3620mL |
1.8099mL |
3.6197mL |
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10mM |
0.1810mL |
0.9049mL |
1.8099mL |
生物活性
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产品描述 |
一种选择性 NK2 受体拮抗剂。 |
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靶点 |
NK2 |
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体内研究 |
Saredutant,an NK2 receptor antagonist,has both antidepressant-like effects and synergizes with desipramine in an animal model of depression.Saredutant has dose-dependent effects on swim test immobility,with the low dose of 1mg/kg having no effect and the doses of 3 and 10mg/kg significantly reducing immobility. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats In the first experiment the dose-related effects of Saredutant are investigated.The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following:vehicle (carboxymethylcellulose-CMC) or 1,3,or 10mg/kg Saredutant,or 5mg/kg Desipramine as a positive control.Saredutant is injected at 1mL/kg.The Flinders Resistant Line (FRL) rats are given CMC or 3mg/kg Saredutant.All injections are i.p.and are given for 14 consecutive days.Approximately 22h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording.Then about 2h later the rats are individually tested in the forced swim test for a single 5-min session. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
