| 中文名称: | SCH28080 | ||||
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| 英文名称: | SCH28080 | ||||
| 别名: | 2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | ||||
| CAS No: | 76081-98-6 | 分子式: | C17H15N3O | 分子量: | 277.32 |
| CAS No: | 76081-98-6 | ||||
| 分子式: | C17H15N3O | ||||
| 分子量: | 277.32 | ||||
基本信息
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产品编号： |
S10984 |
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产品名称： |
SCH28080 |
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CAS: |
76081-98-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
277.32 |
-20℃ |
1个月 |
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化学名： |
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.6059mL |
18.0297mL |
36.0594mL |
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5mM |
0.7212mL |
3.6059mL |
7.2119mL |
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10mM |
0.3606mL |
1.8030mL |
3.6059mL |
生物活性
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产品描述 |
一种可逆的，K+竞争性的胃H,K-ATPase抑制剂，Ki值为0.12μM。SCH28080在体内是有效的酸分泌抑制剂，具有抗溃疡作用。 |
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靶点 |
Ki:0.12μM ((H+/K+)-ATPase) |
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体外研究 |
SCH28080 competitively inhibits the K+-stimulated hydrolysis of ATP,with a Ki of 0.12μM.SCH28080 inhibits histamine-induced [14C]aminopyrine uptake into isolated rabbit parietal cells with an IC50 of 0.029μM.SCH28080 causes a dose-dependent reduction in cell viability with IC50 values of 22.9µM and 15.3µM after 2h and 24h treatments,respectively,and cell viability was below 10% at 100µM already after 2h treatment.SCH28080 induces apoptosis and is cytotoxic at higher doses.SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels,reduces cell viability and dose-dependently induces apoptosis/necrosis. Cell Viability Assay |
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Cell Line: |
INS-1E cell |
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Concentration: |
3.1μM,6.25μM,12.5μM,25μM,50μM,100μM |
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Incubation Time: |
2 hours,24 hours |
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Result: |
Caused a dose-dependent reduction in cell viability. |
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体内研究 |
SCH28080 (20mg/kg;i.p.) inhibits gastric ulcers induced by pylorusligation in rats. |
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Animal Model: |
Male Wistar rat (280-350g),the Shay rat model |
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Dosage: |
20mg/kg |
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Administration: |
Intraperitoneal injection |
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Result: |
Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
