| 中文名称: | ST034307 促销 | ||||
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| 英文名称: | ST034307 | ||||
| 别名: | 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one | ||||
| CAS No: | 133406-29-8 | 分子式: | C10H4Cl4O2 | 分子量: | 297.95 |
| CAS No: | 133406-29-8 | ||||
| 分子式: | C10H4Cl4O2 | ||||
| 分子量: | 297.95 | ||||
基本信息
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产品编号： |
S10066 |
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产品名称： |
ST034307 |
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CAS: |
133406-29-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
297.95 |
-20℃ |
1个月 |
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化学名： |
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one,6-Chloro-2-(trichloromethyl)chromen-4-one |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
'mg/mL |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.3563mL |
16.7813mL |
33.5627mL |
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5mM |
0.6713mL |
3.3563mL |
6.7125mL |
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10mM |
0.3356mL |
1.6781mL |
3.3563mL |
生物活性
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产品描述 |
一种具有镇痛活性的腺苷酸环化酶1（AC1）的选择性抑制剂，IC50：2.3μM。 |
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靶点 |
2.3μM (AC1) |
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体外研究 |
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent.ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2.ST034307 significantly inhibits the forskolin-or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1.In contrast,ST034307 has no significant effects in the wild-type HEK cells.ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates.ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1. |
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体内研究 |
ST034307 (0.25μg) causes a significant relief of CFA-induced inflammatory pain in mice.ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28μg in the mouse pain model. |
推荐实验方法(仅供参考)
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细胞实验: |
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Cell viability assays are conducted with HEK-AC1 cells following plating and compound incubation protocols identical to the procedures described in“cAMP accumulation in cells.”Cell viability is measured as a percentage of vehicle using 2% Triton X-100 as a control.The CellTiter-Glo Luminescent Cell Viability Assay kit from Promega is used to assess cell viability according to the manufacturer’s instructions. Luminescence counts are measured using Synergy 4. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
