中文名称: | (E)-位变异烟碱草酸盐 | ||||
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英文名称: | Rivanicline oxalate | ||||
别名: | (E)-位变异烟碱草酸盐 RJR-2403oxalate;(E)-Metanicotine oxalate | ||||
CAS No: | 220662-95-3 | 分子式: | C12H16N2O4 | 分子量: | 252.27 |
CAS No: | 220662-95-3 | ||||
分子式: | C12H16N2O4 | ||||
分子量: | 252.27 |
一种神经元烟碱受体激动剂。
Metanicotine, also known as RJR-2403 and TC-2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 +/- 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 +/- 155 nM and Emax = 91 +/- 8% for RJR-2403; EC50 = 591 +/- 120 nM and Emax = 100 +/- 25% for nicotine) . Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats. RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )