| 中文名称: | Riluzole hydrochloride | ||||
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| 英文名称: | Riluzole hydrochloride | ||||
| 别名: | Riluzole hydrochloride Riluzole hydrochloride | ||||
| CAS No: | 850608-87-6 | 分子式: | C8H6ClF3N2Os | 分子量: | 270.66 |
| CAS No: | 850608-87-6 | ||||
| 分子式: | C8H6ClF3N2Os | ||||
| 分子量: | 270.66 | ||||
基本信息
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产品编号： |
R10364 |
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产品名称： |
Riluzole hydrochloride |
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CAS: |
850608-87-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
270.66 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.6947mL |
18.4734mL |
36.9467mL |
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5mM |
0.7389mL |
3.6947mL |
7.3893mL |
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10mM |
0.3695mL |
1.8473mL |
3.6947mL |
生物活性
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产品描述 |
一种抗惊厥药物，属于依赖于使用的钠通道阻滞剂家族，它也可以抑制GABA摄取，其IC50值为43μM。 |
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靶点 |
Sodium channel IC50:43μM (GABA receptor) |
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体外研究 |
Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43μM.At 20μM,Riluzole hydrochloride inhibits peak autaptic IPSCs only slightly but prolongs IPSCs reliably.It is also found that Riluzole hydrochloride causes a strong,concentration-dependent,readily reversible enhancement of responses to 2μM GABA.At higher concentrations of Riluzole hydrochloride,especially 300μM,GABA currents exhibit apparent desensitization during prolonged co-exposure to 2μM GABA and Riluzole hydrochloride.The EC50 of Riluzole hydrochloride potentiation of GABA responses is about 60μM. |
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体内研究 |
In normal naïve rats,systemic injection of Riluzole hydrochloride (8mg/kg,i.p.;n=6 rats) decreases the duration of ultrasonic but not audible vocalizations evoked by noxious stimulation of the knee joint compare to vehicle tested in the same rats (P<0.05).Systemic application of Riluzole hydrochloride (8mg/kg,i.p.;n=19 rats) decreases the vocalizations of arthritic rats compare to predrug and vehicle significantly (P<0.05 to 0.001).Riluzole hydrochloride administered into the CeA significantly decreases the duration of audible and ultrasonic vocalizations evoked by noxious stimulation of the knee compare to predrug values (n=8 rats;P<0.05 to 0.01). |
推荐实验方法(仅供参考)
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细胞实验: |
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Two-electrode voltage clamp of Xenopus oocytes expressing exogenous GABAA receptors is performed with a CA-1B high performance oocyte clamp.The extracellular recording solution is ND-96 medium.Riluzole hydrochloride is applied from a common tip via a gravity-driven multibarrel drug-delivery system. Data acquisition and analysis are performed with pCLAMP 6 software. |
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动物实验: |
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Adult male Sprague-Dawley rats (180 to 350g) are housed in a temperature-controlled room and maintained on a 12-h day/night cycle with unrestricted access to food and water.Pain behaviors are measured before and 5h after induction of a mono-arthritis in the left knee joint.To test the effects of systemic (intraperitoneal,i.p.) application of Riluzole hydrochloride,pain behaviors are measured 1h postinjection of Riluzole hydrochloride in normal and arthritic animals.To determine effects of Riluzole hydrochloride into the amygdala,pain behaviors are measured 15 min after starting Riluzole hydrochloride application through a stereotaxically implanted microdialysis probe.To investigate site of action in the amygdala of systemically applied Riluzole hydrochloride,potassium channel blockers are administered into the amygdala 45 min after systemic application of Riluzole hydrochloride and pain behaviors are measured 15 min later,i.e.,1h postinjection of riluzole (i.p.). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
