| 中文名称: | Phenytoin | ||||
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| 英文名称: | Phenytoin | ||||
| 别名: | 苯妥英；5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin | ||||
| CAS No: | 57-41-0 | 分子式: | C15H12N2O2 | 分子量: | 252.27 |
| CAS No: | 57-41-0 | ||||
| 分子式: | C15H12N2O2 | ||||
| 分子量: | 252.27 | ||||
| EINEC: | 200-328-6 | ||||
| EINEC: | 200-328-6 | ||||
基本信息
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产品编号： |
P11297 |
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产品名称： |
Phenytoin |
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CAS: |
57-41-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
252.27 |
-20℃ |
1个月 |
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化学名： |
Phenytoin solution,1.0mg/mL in methanol,ampule of 1mL,certified reference material |
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Solubility (25°C)： |
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体外:
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DMSO |
50mg/mL (198.2mM) |
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Ethanol |
13mg/mL (51.53mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.9640mL |
19.8200mL |
39.6401mL |
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5mM |
0.7928mL |
3.9640mL |
7.9280mL |
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10mM |
0.3964mL |
1.9820mL |
3.9640mL |
生物活性
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产品描述 |
一种有效的电压门控Na+通道(VGSCs)阻滞剂。Phenytoin具有抗癫痫活性，也可减少小鼠乳腺肿瘤的生长和转移。 |
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靶点 |
Sodium Channel |
Virus Protease |
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体外研究 |
Phenytoin is an antiepileptic drug.It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures.Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels.Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials.When neurons are depolarized and the channels transition into the open and inactivated states,greater binding and block occur.The inhibitory potency is strongly use dependent,so that block accumulates with prolonged or repetitive activation,such as occurs during a seizure discharge.The blocking of sodium channels by phenytoin is of slow onset.The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity.Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control.Phenytoin is a class 1b antiarrhythmic. |
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体内研究 |
Phenytoin (5,5-Diphenylhydantoin;60mg/kg;daily;28 days) reduces tumour growth in six week-old female Rag2-/-Il2rg-/-mice with MDA-MB-231 cells. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
