中文名称: | 吡考拉唑 | ||||
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英文名称: | Picoprazole | ||||
别名: | 吡考拉唑 | ||||
CAS No: | 78090-11-6 | 分子式: | C17H17N3O3S | 分子量: | 343.4 |
CAS No: | 78090-11-6 | ||||
分子式: | C17H17N3O3S | ||||
分子量: | 343.4 |
基本信息
产品编号: |
P11295 |
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产品名称: |
Picoprazole |
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CAS: |
78090-11-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
一年 |
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分子量: |
343.40 |
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化学名: |
1H-Benzimidazole-5-carboxylic acid,6-methyl-2-(((3-methyl-2-pyridinyl)methyl)sulfinyl)-,methyl ester |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种特异性的H+/K+-ATPase抑制剂 |
靶点 |
IC50:3.1±0.4μM (H+/K+-ATPase) |
体外研究 |
Picoprazole inhibits the H+/K+-ATPase activity in a concentration-dependent manner.The IC50 value is 3.1±0.4μM.Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme,dose dependently inhibited opening of the Cl-conductance by Cu2+-o-phenanthroline,indicating that the Cl-conductance is part of the function of the H+/K+-ATPase.The inhibitory effect of the three benzimidazole derivatives Timoprazole,Picoprazole,and Omeprazole on histamine and dbcAMP stimulated 14C-aminopyrine accumulation (H+secretion) has been studied in isolated and enriched guinea-pig parietal cells.All compounds tested inhibit H+secretion in a concentration dependent manner with IC50 values of 8.5±1.9μM for Timoprazole,3.9±0.7μM for Picoprazole,and 0.13±0.03μM for Omeprazole. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )