| 中文名称: | Oxcarbazepine | ||||
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| 英文名称: | Oxcarbazepine | ||||
| 别名: | 奥卡西平 GP47680 | ||||
| CAS No: | 28721-07-5 | 分子式: | C15H12N2O2 | 分子量: | 252.27 |
| CAS No: | 28721-07-5 | ||||
| 分子式: | C15H12N2O2 | ||||
| 分子量: | 252.27 | ||||
| EINEC: | 249-188-8 | ||||
| EINEC: | 249-188-8 | ||||
基本信息
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产品编号： |
O10294 |
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产品名称： |
Oxcarbazepine |
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CAS: |
28721-07-5 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
252.27 |
-20℃ |
1个月 |
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化学名： |
9-oxo-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene-2-carboxamide |
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Solubility (25°C)： |
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体外:
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DMSO |
7mg/mL (27.74mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.9640mL |
19.8200mL |
39.6401mL |
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5mM |
0.7928mL |
3.9640mL |
7.9280mL |
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10mM |
0.3964mL |
1.9820mL |
3.9640mL |
生物活性
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产品描述 |
抑制[3H]BTX与钠离子通道的结合，IC50为160μM。 |
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靶点 |
Sodium Channel. |
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体外研究 |
Oxcarbazepine significantly inhibits glioblastoma cell growth and reaches IC50 at therapeutic concentrations.The IC50s of Oxcarbazepine screened with the U87 and T98 cell lines are 12.35 and 9.45μg/mL,respectively. Cell Viability Assay |
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Cell Line: |
Human glioma cell lines U-87 MG and T98G |
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Concentration: |
2.5,5,10,20,and 40μg/mL |
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Incubation Time: |
72 hours |
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Result: |
The growth inhibition for the T98G cell line for each concentration was 17.7±4.1% (2.5μ g/mL),21.1±3.6% (5μg/mL),53.6±14.2% (10μg/mL),82.2±2.3% (20μg/mL),and 85.0±2.3% (40μg/mL).The growth inhibition for U-87 MG cell line for each concentration was −1.7±5.1% (0.008μg/mL),5.3±2.4% (0.08μg/mL),3.5±7.4% (0.8μg/mL),0.3±9.2% (16μg/mL),and −4.2±9.6% (40μg/mL). |
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体内研究 |
Oxcarbazepine protectes mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5mg/kg p.o.No tolerance toward this anticonvulsant effect is observed when rats are treated with Oxcarbazepine daily for 4 weeks. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
